PLEASE READ--KPU major player in autism; our magic bullet!

Discuss autism diets and biomedical treatments of autism.

Moderator: ModeratorBill

Pearl1981
Posts: 638
Joined: Sun Jul 17, 2011 7:48 pm

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby Pearl1981 » Fri Sep 23, 2011 8:46 am

Ive not agreed with his method of chelation, so I have been continuing with andy cutlers chelation and will be adding KPU minerals as well, when the time is right.

Everyone should look up his lecture notes for a much more comprehensive explination, one can not go by the video alone. The notes are much more informative and accurate than his lectures. He gives doses and steps to follow regarding the definate need to chelate autistic children before giving KPU supplements.

Theres lots on the net. Dr Mercola has a few and so does Dana from thriive. Tamaro protocol has a few of his publications as well.

I also posted a few pages here on this thread. I could repost all of them if anyone is interested to see. Ive gathered as many as I could and pasted them all on my PC for reference.
Daughter 5y.o lost diagnosis - 100 rounds cutler. Aspergers/ autism @2yrs

amanda NC
Posts: 3037
Joined: Fri May 25, 2007 7:41 am

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby amanda NC » Fri Sep 23, 2011 8:48 am

Oh--Kirkman has a zinc sulfate cream that will bypass the gut, and then you won't have the nausea issues so common with this. I have it and am experimenting. the nausea is supposed to go away, so the cream would not be needed forever, but you could switch to the pills when the stomach acid is normalized.

Thanks Pearl. There is a bunch of stuff out there! So hard to round it all up! Thank you for posting what you have; I had not seen most of it and am still digging through it all!
Amanda, mom of 3

Pearl1981
Posts: 638
Joined: Sun Jul 17, 2011 7:48 pm

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby Pearl1981 » Fri Sep 23, 2011 9:25 am

no problem amanda :)
I wanted to do my research as well as I could:



8•Repair
7•Microbes and Biofilm
6•Toxin Elimination Full dose KPU protocol, mehylation support, systemic sulfhydryl complexing agents, start low doses of biofilm enzymes
5•Clean House/KPU (Pyrroluria)
4•Binders, microsilica, chlorella, clays (charcoal or acute reactions), calcium EDTA suppositories, slowly start KPU protocol, consider liver/gallbladder flush
3•Foundational Tamaro Vitamin K Protocol, add green clay,microsilica and/or chlorella to help with symptom management.
2•Top 10 List
1•Delete multi-vitamin and calcium supplementation and add multi-mineral



•Porphyrin
•pH, temperature and hair analysis
•Test home for mold and EMF's, temperature, pH and pulse rate



this is LONG

THRiiiVE Summit – August 15, 2009

Attendees

Dana Gorman – THRiiiVE

Amy Derksen, ND

Deitrich Klinghardt, MD

Joe Mercola, DO

Tami Duncan – LIA Foundation

Anju Usman, MD

Catherine Tamaro

Linda Garcia

Chris Ashley

Keith Morey – Super Good Stuff

Jim Hazinger – World Health Mall

Ed Smith

Jorge Moreno, DO

George Gonzalez, DC, QN



Catherine Tamaro

http://health.groups.yahoo.com/groups/VitaminK

We have 48 nuclear receptors which signal gene expression. RXR responds to DHA.

Nuclear Receptors which require Vitamin A (RXR) Activation for signaling RXR:

· Retinoic Acid Receptors

· Vitamin D Receptor

· PPAR Receptors - Inflammation (upregulated by phosphytalcholine and phosphytalserine)

· Nerve Growth Factor (homeopathic?)

· ROR/Purkinje Cells

· Nurr-1/Dopamine

· Rev-Erb/Dopamine

· Liver X Receptor/vitamin K2

· FXR/bile salts, small intestines defense

· CAR/detoxification, bilirubin



Nuclear Receptors Which Repress Vitamin A (RXR) Activation

· Androgen Receptor/Testosterone (if one is signaling, the other is silenced – giving vitamin would suppress the testosterone)

Vitamin A can be used then to suppress testosterone.

Fermented Cod Liver Oil is high in vitamin A (Weston Price Site) or eating organ meats and DHA. Be careful about the liver because it is high in copper. Source needs to come from animal or a fish. Water soluble Vitamin A is 10 x’s as toxic as an oil based vitamin A.



The problem isn’t in the conversion, but the issue lies in the signaling of the receptors. DK mentioned that the signaling is disrupted by EMF exposure.



High calcium, ionized is high is bioactive which causes the signaling problems.



Kidneys – abnormal lab tests



Mineral suggestions

Angstrum Liquid Phosphorous – goes straight to kidneys and helping the acid come out. Divided doses during the day.



Supplemental ATP?



Dairy is the major source of phosphorous which should be thought about when doing the GFCF diet. Supplementation should be considered.



DK - Urine should be more acidic than saliva – 6.7 urine and 6.2 for saliva is the goal and if off balance phosphorous may balance that. (value can flex 0.2) Could be why children have problems potty training because of the ph level in the urine, too acidic.



Vitamin K2 Thorne dose – 1 drop per 10 lbs body weight



Biofilm



Discussion on biofilm protocols with Anju Usman, MD

Niche’ bacteria cannot be replaced with probiotics

Colitis as an autoimmune disorder, body fighting its own bacteria both good and bad.

Low ferritin and low iron in the kids

Iron levels go up when breaking up the biofilm

Heavy metals being sequestered in the biofilm with the bugs

New products from Klaire – Interphase protyletic enzymes ( must start very low dosing)

- Launch Biofilm Defense from True Health Pharmacy in October will be a better product with the best of all the ingredients.

Giving calcium while killing bugs will not be good.

Re-establishes fermentation in the gut – Healthy Gut by World Health Mall

Changes in ph can shift when killing biofilm.

Salt can breakdown biofilm

DK mentioned that silica can breakdown biofilm. New silica product from BioPure. They also have a product called “It Works” by Super Good Stuff.

Silver and hydrogen peroxide in a nebulizer could kill biofilm in the lungs. (World Health Mall)



Vitamin K Protocol



Goal of protocol: move children to homeostasis (balance), maintain appropriate pH, temperature, detoxify, eat a ariety of foods without responding and defend ourselves against micro-organisms.







Protocol accomplishes---

pH control

Rehydration

Metabolic Improvement

It takes about 4-6 months to get child full adjusted to the vitamins and past the detoxification that the electrolyte drink initiates



Baths

8 cups baking soda per bath

Every 3 rd or 4th bath use 2 cups of sea salt instead of the baking soda

Baths can be given daily or 2 x day

Purpose: absorption of bicarbonate or salt for kidney function and pH management

Baking soda is available in 12 lb bags at Costco or Sam’s club.



Dehydration – electrolyte drink

Glucose (honey (2 tlbs), grape juice or young coconut water)

Coconut may be the best choice due to the added nutrients

Salt (potassium chloride) (Now Foods makes a potassium chloride) ¼ tsp

Bicarbonate (baking soda) (Klaire labs also makes a bicarbonate) ¼ tsp

(hydrates cells, upregulates detoxification)



Magnesium

Magnesium Glycinate or Magnesium Malate?

Recommended dose – 400-800mg/day depending on age, size and bowel tolerance



Phosphorus

Carlson Complexed Phosphorus Tablets

Angstrom Minerals Liquid Phosphorus

Liquid is much easier to use

Must be given in divided doses (3-4 x per day) (dose may be 2-3 tsp for 5 yr old – adjust per weight/age)

Purpose: Beneficial for kidney function – appears to improve renal acid excretion

DK suggested homeopathic phosphorus as a possibility



ATP

All organisms break down food, extract energy from it and use the energy to manufacture ATP

ATP is manufactured in the mitochondria of the cells. It is what cells use for their source of energy as they go about their daily business.

All cellular metabolic processes require ATP. Those metabolic processes include DNA replication, cell division, cell repair, cell defense, cell-to-cell communication, and cell growth. All chemical reactions in the body require ATP.

D-Ribose good to take with the ATP.

(DK suggested research in which D-Galaktose does a better job – http://www.purren-apotheke.de - available in Germany)

ATP = Beyond A Century http://www.beyond-a-century.com or progressive labs. Comes in a powder, don’t get the tablets because they have calcium

Once child is doing well on the above, begin the fat soluble vitamins. All of these work TOGETHER.



Vitamin A – must be Cod Liver Oil or from food

Pollutants and pesticides have a direct effect on Vit. A levels and metabolism. Toxin and illness cause the Vit. A to be used faster.

Brands – Green Pastures, Dr. Ron’s, or Radiant Life – NO MYCELLIZED Vit. A

Dose can be up to 15K IU for the bigger kids. Min. of 5K IU for a small child.



Vitamin D3

Must be vitamin D3

Dose is 75IU per pound body weight or 165 IU per kg body weight

Blood levels of 25 hydroxy exceeding 80ng/ml have shown the most improvement in immune response.

Brand – drops from Biotics – Mercola has a D3 spray which is something to check out



Vitamin K2

Controls calcium – puts the calcium in the bones where it belongs and keeps it out of soft tissues and organs, where it doesn’t belong.

Plays a role in myelin formation

May be effective against biofilm due to its calcium-binding action

Activates transthyretin, which transports Vit. A and thyroid hormone in the brain

Has been shown to be deficient in healthy European children.

Is an approved treatment for osteoporosis in Japan.

Brand – Thorne K2 – dosed 3 x per day

No toxic dose has been found – Vitamin K1 and K7 is NOT an acceptable substitute

May see improvements in teeth.



DHA

Any brand of a DHA supplement. ½-2 grams dose. DHA to EPA ratio is not important.



Potassium Iodide -SSKI

Initial dosing is very high, in order to “load” the body with iodide.

Dose is gradually reduced over several months to maintenance level.

Dosing is based on the approach pioneered by Dr. David Brownstein.

Mix it in water and take orally

Metallic taste in mouth is probably a detox response which will go away

May have some antimicrobial properties

Thyroid improvement and less illness may be seen

Lower rate of breast cancer in Japan due to increased Potassium Iodide intake in Japan

Tri-quench







Melatonin

Effective immune modulator and anti-inflammatory

Large doses have been used successfully with sarcoidosis patients

Adults make progressively less melatonin as they get older. A dose of 3mg/night has been shown to delay the onset of menopause.

Dose – 2-10mg/night

DK mentioned if it makes one NOT sleep at night, to just take it in the morning.



Phosphatidylcholine



Phosphatidylserine

100-1500 mg helps with hyperactivity



Calcium

Should be obtained from FOOD NOT SUPPLEMENTS



After all supplements are in place…

1. It will take 4-6 months to get your child fully adjusted to the vitamins and past the detoxification that the electrolyte drink initiates.

2. Manage detoxification (glutathione, l-cysteine, Epsom salt bath?)

3. Once the child is past most of the detoxification intensive anti-microbial therapy is appropriate.



DK suggests that detox is important but PKU protocol needs to be looked at next.

Keith Morey suggested in starting with giving something rectally to get some of the gut bugs under control



Linda Garcia and Chris Ashley



Autism and Impaired Methylation:

A working model for Symptoms, Consequences and Strategies



Methylation is one aspect of epigenetics. It is governed by these enzymes in the liver and in the brain. DNA methylation = the body using methyl groups to turn on and off our genes

Hypothesis: When this “factory” isn’t running well we can become susceptible to many modern diseases.



From their research and experience, including working with Jeremy Kaslow they can…

· Accurately predict genetic mutations based on symptoms

· Predict response to various foods, supplements and treatments

· Predict outcomes of some laboratory tests

· Accurately bypass certain mutations

· Improve methylation to the point that unassisted heavy metal excretion can occur for the first time in some of our children.



Independent sources for reputable genetic testing and gene information

http://www.genecards.org

http://www.ncbi.nlm.nih.gov/sites/GeneT ... =GeneTests

http://www.epigenome-noe.net/aboutus/epigenetics.php

http://www.googlescholar.com

http://www.ncbi.nlm.nih.go/pubmed/



*Bruce Ames – research on bypassing snp/mutation with co-factors



Many different diseases coincide with these methylation abnormalities



Livability index = do you want to do this, can you do this?

By doing some supplements you may fix something but cause another problem by leaning on other weaker pathways. It could also be a ph shift from the detox. It could also shift the neurotransmitters causing rage, self-injurious behaviors, etc.



You can either have the mutation or your body can “act” like you have the mutation due to pathogens.



What should be done to optimize methylation?



· Aggressively address and maintain GI health

· Identify / address mitochondrial dysfunction

o Address elevated lactate or pyruvate first

o Avoid disrupters (hydrogenated oils, toxic metals, chemicals, fluoride, pesticides

o Run OAT tests

o Chart results against metametrix diagram to pinpoint possible roadblocks

o Trial supplements/foods to bypass roadblocks carefully choosing least offensive, purest forms

o Consider R5P (Thorne), Germanium (improves low pulse-ox can get from celery)

· Address dysfunctional transsulfuration

o Pale, dark circles under eyes, headaches, migraines, asthma, unexplained bruises, failure to thrive, low muscle tone, fetal position when testing, hypoglycemic tendencies, gi problems, spacy, low attention to environment, speech/language difficulties, stims, difficulty with reading or math even with high intelligence, manufactures own stress/fear, symptoms associated with neurotransmitter difficulties (anxiety, low focus/attention, difficulty sleepint)

o Not producing co-q10, carnitine, methyl groups

o Bypass CBS (turmeric/quercetin by Liver nano-detox – Premier Research), PDA to Sulfur Laser detox/Asyra, minimize EMF

o (Enhansa for effective tumeric http://www.ourasdkids.com )

o Minimize its consequences of excess – ammonia, sulfites/sulfites (molybedum helps this can get from world health mall), alpha-ketoglutarate, glutamate, hydrogen sulfide, cortisol, blood sugar abnormalities.

o Avoid and minimize – sulfur containing supplements, sulfur based foods, methylation support, assisted detox/chelation, b6/p5p.

o Address BH4

· Address excess ammonia

· Address BH4 deficiency (Kuvan? Pharm.)

o Ensure proper thyroid function

· Address reactive oxygen species generation

· Address methyl cycle abnormalities



Gut pathogens, CBS upregulation and mitochondrial dysfunctions they have the same effect

- Impair glutathione production and detoxification

- Accumulation of toxins weakens methylation

- Failure to address explains part of the degradation in some ASD children

- Toxic metabolites are produced

Priority should be given to the following

- Addressing mito dysfunction, especially elevated lactate or pyruate

- Dealing with CBS upregulation

- Dealing with gut pathogents

- Putting together a toxic metabolite mop toolbox



You can’t fix cycles one at a time – have to fix them all of the time

Fix one thing, break another plays out

Meythl B-12 will work to fix some pathways but not all of them. Shots would be the best to do a therapeutic trial. Other forms of MB12 are not proving to work as well.



MTFHR - they need the methyl folate and the mb12 it will be trapped.



Optimizing Methylation: The more you lean, the bigger you mop needs to be

MAO A possible symptoms

Anxiety

Mood swings

Sleep difficulties

Lack of focus/attention

Chronic strep

Citrus/beef intolerance

Seizures

Tremors

Myoclonic spams

Mg? intolerance

Sentiity to phenos, amines and foods high in glutamate

Warning: individuals with neurotransmitter issues should avoid Fava and Broad beans



ACE deletion

Sodium/potassium imbalances

Kidney issues

Low frusteration threshold

Increased anxiety

Learning problems

Cardiovascular disease

Avoid grapefruit juice or licorice



MTHFR Folic Acid Cycle (677)

Must give methyl-folate to bypass – small doses



SHMT Folic Acid

Methyl Folate

Folinic



MTR Intersection of Folic Acid and Methionine Cycle

MB12

Methyl Folate

SAMe if tolerated



MTRR Intersection of Folic Acid and



COMT “BH4” or Neurotransmitter Cycle

Migrains, mood swings, screaming, seizures

Give Mango



See Power Point for more details

SEND study on sarcoidosis and lyme disease to Catherine



Keith Morey – http://www.supergoodstuff.com



Always check body temperature – under 98.2 deactivate enzymes. One can’t digest food or chemicals to kill fungus. Liver and digestion is stuck when temperature is too low. If the temperature is OK then you will go in to detox. Otherwise will need to do protocol.



Success = temperature rising = thyroid functioning



Taking temperature – oral thermometer before noon on empty stomach and again at 3:30 on empty stomach.



Thyroid – adrenal cortex, adrenal calm k9 and k12 from Apex, Total Recall, Rice Bran soluble, EnduraMaxT Nrgy to rebuild the thyroid , liver/gallbladder flush and paramunes.

Physical and mental stress goes down



Gallbladder is the key to the healing process. Liver needs to eliminate. His flush is an adapted Hulda Clark flush. He adds electrolytes and the Xylitol with Beta Glucan, emergenC, Taurine. At 10 p.m. 2 oz fleet enema – 20 drops of paramune and paramune 5 . Do the grapefruit/olive oil with two capsules of the paramune taken orally. His full protocol can be found on his website. No carbohydrates for 36 hours after the flush.



Detox program

MSM

Dehydration – takes sulphur and helps the ionic exchange with sodium, which hydrates the cells allowing toxins to be pumped out.

Inflexibility – Dumps the waste material

Insulin Resistance - Now cell is getting fed properly

Creates a huge amount of diahrrea as it breaks up the microbial colonies in the gut

Headache

TMG

Vitamin C

Rootin

Potassium

Nasal Wash for Sinus Cavity

Paramune and Paramune 5 – 3 x day rectally (severe case) or orally – rarely any bad reactions from these



After 5 days on this protocol do another liver/gb flush



5 days of detox program

Cravings for carbohydrates increase around day 3-4. About day 5 they begin to decrease.



DK mentioned that if a child has a sulfur issue, then to go full dose do NOT ram up because a negative reaction may not happen, but will if low doses are given.



Dietrich Klinghardt, MD – Pyrroluria (KPU)



Kryptopyrroluria test – tests for hemopyrolactins in the urine



Other names for pyrroluria _ Malvaria, Mauve, HemoKryptolactamuria



82% of ASD children test positive for KPU – ridiculous not to test this population for this



Condition can be induced by psychological childhood trauma AND chronic infections.

(98% of Schizophrenics have this biomarker) The childhood trauma could be from past generations. (passed from mom to child or parent child) This is interesting because the methylation defects can also be passed along through the generations. Passed in the epigenome (not the DNA)



If one has Lyme disease 5 years or more, they have increased amounts in their system.



KPU is an induced condition in infections. Any chronic infection that has been there long enough will cause this condition. This condition could disable the entire immune system.





Test: Vitamin Diagnostics –Hemopyrrolactum test ($60 test plus shipping)

15 is the upper reference range – anything twice normal or more is severe. (over 30)

Must use strict instructions on submitting to the lab. Lab does not give proper instructions.



24 hour urine test for KPU – Use cleaned large orange or mile juice carton for collection. Add 500mg of ascorbic acid per liter of urine to stabilize pyrrols. Wrap aluminum foil around collection container and transport-tube to prevent light induced pyrrol breakdown. Keep container in the refrigerator (cold). Shake the container vigorously before putting in the collection tube. Then FREEZE the tube and wrap in aluminum foil. Include ice pack and then send to the lab overnight. Then call the lab to let them know it needs to be kept in the fridge or freezer until they run the test.



Preparation for the test:

Do not take vitamins 5 days prior to test (especially B vitamins and minerals)

Exposure to normal daily stresses is needed (no stress-avoidance or rest)



· KPU is caused by the defect of several of the 8 enzymes needed for the synthesis of heme

· Heme is needed for liver detox reactions, cystathionine synthase, catalase, heme-hemopexin for MT translation, guanylate cyclase, sulfite-reductase, NOS, pyroolase.

· KPU patients have low serum glutathione levels, high NO levels, low histamine

· KPU can be inherited or can be acquired

· Downs – 70%, Schizophrenia 40-70%, autism – 50%, aDHD – 30%, ETOH 20-80%, Lyme and co-infections – 80%



Symptoms

Poor dream recall

Poor breakfast appetite

Nail Spots (1/3 patients have this)

Stretch marks

Pale skin / Poor tanning

Acne, allergy, obesity

Course Eyebrows

Knee and joint pain

Cold hands or feet

Abdominal Tenderness

Constipation

Eosinophilia

Light/Sound/Odor intolerance

Tremor/shaking/spasms

Leaky gut symptoms – disappears when you fix the KPU

KPU patients lose B6, Taurine, Zinc instead of binding the toxins in the liver



Zinc taste test does not work – do not use



Biotin is very important for the body and the body is not created in the body well enough. It is created in the gut and since the immune system is disarmed there is no healthy bowel formula.



IV glutathione has NOT given the results that it should be and it would be better to do other supplements.

Nitric Oxide



EFT (Emotional Freedom Technique) can flip the switch if you have one polymorphism on one gene…since the other one doesn’t there is no reason to think that the defected gene is the one that is transcribing.



Nitric Oxide is the cycle affected

Methylation Cycle affected – DMG, Zinc, B6



Need the co-factors in order to make the genes work. Detox ability is the biggest problem in all of these illnesses. Once the detox is turned on a huge healing crisis may come and help with metal detox may be necessary. Coffee enemas and colonics may be very necessary to work through the crisis.



Treatment for KPU



a.m. before breakfast:



*Zinc 250 mg/day for 3-4 months (picolinate, gluconate or sulfate) 1mg/pound of body weight (Zinc may cause naseau)

Later in the treatment less zinc may be needed for maintenance



*Manganese 10-30 mg/day (1/5 of the Zinc dose total daily)

with breakfast

Arachidonic acid from Omega-6 oils: evening primrose, ghee, borage oil,

black current oil

p.m. before bedtime:

*P-5-P 50 mg, B 6 25 mg (1/3 of Zinc dose)

*Magnesium 600 mg (Magnesium Glycinate)

MicroMinerals 1 tbsp (BioPure)



• psychiatric symptoms: Niacinamide 1000 mg tid

• *brain: seizures, fog, memory loss: Taurine 500 mg tid.

• *skin/hair/nail symptoms: Biotin – 15mg per day ( 1/10 of the Zinc dose)



other considerations:

high gamma vit E: 400 i.u per 40 lbs weight, fish oil 1 tsp/day

Zinc depletes copper levels. Some patients are or become copper deficient.

There is much misinformation regarding copper in the current nutritional

teachings. Beware. Monitor with red cell mineral test and replace if indicated (3-6 mg/day)

Always have metal- detox agents on board (DMSA, Phospholipic Exchange)



Metal Detox while for people who have NOT done chelation before



· Turn on phase 1,2,3 detox – sound wave enhanced chlorella (15 tbl t.i.d.) with meals (BioPure)

· Mobilize by trying to route the metal detox through the gut instead of the kidneys.

· Cilantro used as a mobilize and Chlorella as the capture agent

· KPU usually have a tough time chelating on their own from the inner cellular environment

· Liver/gallbladder flush, castor oil packs, colonics is a good place to start as foundational.



1. Clear up metals has managed to mobilize to the surface – Electroylte Water (M Water), Make till you can taste a bit of the electrolytes. Catherine Tamaro Vitamin K protocol for 2 – 4 months. Also add the micro-silica on the first visit. ( 4 yr old – 1 scoop 2 x day diluted in a lot of water by BioPure)

2. EDTA suppositories for about 2 months

3. Add in the DMPS / oral DMSA, glutathione, NAC whichever tests the best for another 2 months

4. Then do the KPU treatment – will need major detox supports as metals will begin to spill again.



For those who HAVE done chelation

1. KPU treatment
Supplement Protocols
Motivation Creating Tests

PH – Saliva/Blood and Urine

OAT Test

Urine Porphyrin

Hair analysis

Stool Test for baseline

Urine Mycotoxins

Kamsteg Questionnaire (KPU questionnaire)

Temperature Test?

Pulse Test

Graduation Criteria

Symptom Specific Solutions

Subject: FW:
Date: Tue, 6 Sep 2011 17:18:12 +0100

Mercury and The Human

Detoxification System

Christopher W. Shade, Ph.D.

Quicksilver Scientific, LLC

Lafayette, CO 80026

(303)263-6903

chris@quicksilverscientific.com

Saturday, 11 September 2010

Mercury and The Human

Detoxification System

1. What are the key forms of Hg

2. How the Detoxification System Works

3. Methylmercury Accumulation as a hidden

danger in Amalgam toxicity

4. Intestinal Metals Detox System to repair

and amplify the bodies detoxification

mechanisms and safely remove mercury

Saturday, 11 September 2010

Transport of mercury

• Hg0

– 80% uptake in lungs, crossed BBB, diffuses in to

tissues; moderate uptake from intestines

• HgII

– Very poor uptakes in intestines; poor mobility; does

not cross BBB

• MeHg

– 95% uptake from intestines, good mobility, crosses

BBB

• EtHg

– 100% absorbtion (inj), good mobility, crosses BBB

Saturday, 11 September 2010

The Heart of the Toxicity

1. Inappropriate Binding

2. Oxidative Damage and related

Inflammation

Saturday, 11 September 2010

The Heart of the Toxicity

• Thiol Binding and Redox Reaction

– Reduced sulfur groups, R-SH,

– Hg replaces proton and binds to sulfur

• R-SH + Hg2+ = R-SHg+ + H+

– Enzymes use thiols to anchor functional metals (Zn,

Ni, Cu, Fe)

– Bind and alter membrane or trigger membrane

reorganization and consequent auto-oxidation

– Oxidize Thioredoxin (protein repair molecule)

– Deplete Glutathione system

Saturday, 11 September 2010

Defense – Glutathione System

Antioxidant, Detoxification, Protein Repair

• Glutathione (GSH) - A thiolic tripeptide

composed of glutamate, cysteine, and glycine

• The system involves

– Synthetases (synthesize GSH from precursors)

– Transpeptidases (take apart and reassemble)

– Transferases (conjugation)

– Peroxidases (radical quenching)

– Reductases (repair after quenching)

– Redoxins (using GSH as reducing equivalent for

protein repair)

Saturday, 11 September 2010

• Detoxification Phases I, II, III

–Phase I is an activation,

–Phase II is conjugation

–Phase III is transport

The Human Detoxification

System

Saturday, 11 September 2010

• Phase I - an oxidative activation, usually

the Cytochrome P450 system

– Prepares toxin for conjugation in Phase II with

GSH, Glucuronic acid, Sulfate, Gycine or

other amino acid, Taurine, Methyl group

– Not needed for metals, but very important to

have coupled to Phase II

• Creates Essentially Free-Radicals

The Human Detoxification

System

Saturday, 11 September 2010

• Phase II – conjugation makes toxin more

water soluble and recognizable by

transporters

– Glutathione S-Transferases (GST)

responsible for GSH conjugation

– Low in people with high MeHg and with

sensitivity to Thimerosal (EthylHg)

The Human Detoxification

System

Saturday, 11 September 2010

• Phase III is the transport out!

– Several transport proteins (cMOAT, OAT,

MRP1, MRP2, GS-X)

– Same transporters for many pathways

(glucuronide, sulfate, glycinate, GSH)

– In cells, liver, intestines, kidneys – biggest in

liver then intestines

The Human Detoxification

System

Saturday, 11 September 2010

Breakdown of the defense

system

• GSH deficiency – genetic and/or

environmental

• GST problems – genetic and/or

environmental

• Phase III can get blocked and then

downregulates Phase II enzymes

–Can stop multiple detoxification

pathways!

Saturday, 11 September 2010

Biggest Reason for Phase III

Dysfunction

Saturday, 11 September 2010

Biggest Reason for Phase III

Dysfunction

Inflammation in Gut!

-Hallmark of Autism cases

-Easily caused by heavy metal

induced oxidative damage

Saturday, 11 September 2010

Phase I

Phase III

Phase II

Glutathione

Conjugation

Sulfation Glucuronidation

OATP

Blood

LIVER

MRP2

Normal Small Intestine

Cellular MRP1

Oxidative Activation

Saturday, 11 September 2010

Phase I

Phase III

Phase II

Oxidative Activation

Glutathione

Conjugation

Sulfation Glucuronidation

OATP

Blood

LIVER

MRP2

Inflamed Small Intestine

Cellular MRP1

Negative

Feedback –

Inhibition of

Phase II

Inflammation

causes

Downregulation

of MRP2

Oxidative Stress From

Phase I/Phase II mismatch

Build-up of both

cellular and

blood-borne

toxins

Saturday, 11 September 2010

Accumulation

• Retention Toxicity – Phase II, III problem?

– Genetic difficulties: GS, GST deletions

– Acquired Dysfunctions: Transporter

impairment, severe oxidative stress

Saturday, 11 September 2010

MethylMercury

The Unsuspected Factor

H

H H

Hg

Saturday, 11 September 2010

Accumulation

Enterohepatic

Circulation of MeHg

H

H H

Hg

Saturday, 11 September 2010

Accumulation

Enterohepatic

Circulation of MeHg

H

H H

Hg

Saturday, 11 September 2010

Synthesis of Methylmercury

from Amalgam-Derived Hg

Saturday, 11 September 2010

Synthesis of Methylmercury

from Amalgam-Derived Hg

Experimental Results in

Monkeys

w/ Dr. Anne Summers, University of

Georgia

Saturday, 11 September 2010

0.001

0.010

0.100

1.000

10.000

100.000

-23 -1 10 17 60 66 80 94

0.01

0.10

F78

HgT*/T (ug/gm)

Day

MeHg (ng/gm)

QuickSilver HgII Calgary HgT MeHg

0.001

0.010

0.100

1.000

10.000

100.000

-79-74-60-46-235 121928405473848998119133159

0.00

0.01

0.10

1.00

10.00

R87

HgT* (ug/gm)

Day

MeHg (ng/gm)

QuickSilver HgII Calgary HgT MeHg

Continuous In Vivo Synthesis of CH3HgX from Amalgam Hg

by Intestinal Bacteria in Live Monkeys

0.010

0.100

0.001 0.010 0.100 1.000 10.000 100.000

R² = 0.5255

F78

MeHg (ng/g)

HgII (ug/g)

0.001

0.010

0.100

1.000

10.000

0.001 0.010 0.100 1.000 10.000 100.000

R² = 0.7097

R87

MeHg (ng/g)

HgII (ug/g)

Time course CH3HgX as a fraction of total Hg

16 occlusal

amalgams

placed

12 occlusal

amalgams placed

removed

Saturday, 11 September 2010

In-Gut MeHg

Synthesis H

HH

Hg

MeHg synthesized from HgII

derived from amalgam corrosion.

MeHg absorbed ~95% efficiency

versus the 5-10% of HgII.

Continuous Synthesis plus

recirculation can lead to high

body burden of MeHg

Saturday, 11 September 2010

In-Gut MeHg

Synthesis H

HH

Hg

MeHg synthesized from HgII

derived from amalgam corrosion.

MeHg absorbed ~95% efficiency

versus the 5-10% of HgII.

Continuous Synthesis plus

recirculation can lead to high

body burden of MeHg

Saturday, 11 September 2010

Testing for MeHg

H

H H

Hg

Saturday, 11 September 2010

Testing for MeHg

• Old Dictum – blood is only recent exposure, 3-days

H

H H

Hg

Saturday, 11 September 2010

Testing for MeHg

• Old Dictum – blood is only recent exposure, 3-days

• Reality

H

H H

Hg

Saturday, 11 September 2010

Testing for MeHg

• Old Dictum – blood is only recent exposure, 3-days

• Reality

– 3-day residence only the quick decay after a large

dose

H

H H

Hg

Saturday, 11 September 2010

Testing for MeHg

• Old Dictum – blood is only recent exposure, 3-days

• Reality

– 3-day residence only the quick decay after a large

dose

– For MeHg, Steady state develops after initial decay;

Then blood reflects body burden!

H

H H

Hg

Saturday, 11 September 2010

Testing for MeHg

• Old Dictum – blood is only recent exposure, 3-days

• Reality

– 3-day residence only the quick decay after a large

dose

– For MeHg, Steady state develops after initial decay;

Then blood reflects body burden!

• Real Problem

H

H H

Hg

Saturday, 11 September 2010

Testing for MeHg

• Old Dictum – blood is only recent exposure, 3-days

• Reality

– 3-day residence only the quick decay after a large

dose

– For MeHg, Steady state develops after initial decay;

Then blood reflects body burden!

• Real Problem

– Most labs detection limits too high to see dynamics

H

H H

Hg

Saturday, 11 September 2010

Testing for MeHg

• Old Dictum – blood is only recent exposure, 3-days

• Reality

– 3-day residence only the quick decay after a large

dose

– For MeHg, Steady state develops after initial decay;

Then blood reflects body burden!

• Real Problem

– Most labs detection limits too high to see dynamics

– Need sensitive equipment!

H

H H

Hg

Saturday, 11 September 2010

Testing for MeHg

H

H H

Hg

Saturday, 11 September 2010

MeHg

HgII

MeHg

HgII

H

H H

Hg

Testing for MeHg

Saturday, 11 September 2010

The Great Tuna Experiment

• Wade Wimer – 2 cans of Albacore Tuna in one sitting

2 hours later

24 hours later

0

0.75

1.50

2.25

3.00

10/26/08 10/27/08 10/28/08 10/31/08

Blood MeHg (ng/mL)

2 hours later

24 hours later

Pre-Tuna

Saturday, 11 September 2010

The Great Tuna Experiment

• Wade Wimer – 2 cans of Albacore Tuna in one sitting

2 hours later

24 hours later

0

0.75

1.50

2.25

3.00

10/26/08 10/27/08 10/28/08 10/31/08

Blood MeHg (ng/mL)

2 hours later

24 hours later

Decay – Excretion? Redistribution to Tissues?

Or some of Both?

Pre-Tuna

Saturday, 11 September 2010

Testing for MeHg

H

H H

Hg

Patients with high MeHg take much longer to

recover!

-testing can give indication of rate of

recovery

Dr. Huggins Observation

Saturday, 11 September 2010

Removal of Hg

Amplifying and Augmenting Natural

Systems

Saturday, 11 September 2010

Product/System for Intestinal

Detoxification

Saturday, 11 September 2010

Product/System for Intestinal

Detoxification

• MicroSilica (IMD)

Saturday, 11 September 2010

Product/System for Intestinal

Detoxification

• MicroSilica (IMD)

– Use Intestines NOT Kidneys for Metal Removal

Saturday, 11 September 2010

Product/System for Intestinal

Detoxification

• MicroSilica (IMD)

– Use Intestines NOT Kidneys for Metal Removal

– Insoluble Spheres saturated with strong binding groups

Saturday, 11 September 2010

Product/System for Intestinal

Detoxification

• MicroSilica (IMD)

– Use Intestines NOT Kidneys for Metal Removal

– Insoluble Spheres saturated with strong binding groups

– Binds Mercury in Intestines and moves out of Body

Saturday, 11 September 2010

Product/System for Intestinal

Detoxification

• MicroSilica (IMD)

– Use Intestines NOT Kidneys for Metal Removal

– Insoluble Spheres saturated with strong binding groups

– Binds Mercury in Intestines and moves out of Body

• Stops Enterohepatic Circulation

Saturday, 11 September 2010

Product/System for Intestinal

Detoxification

• MicroSilica (IMD)

– Use Intestines NOT Kidneys for Metal Removal

– Insoluble Spheres saturated with strong binding groups

– Binds Mercury in Intestines and moves out of Body

• Stops Enterohepatic Circulation

• Opens Phase III transporters

Saturday, 11 September 2010

Product/System for Intestinal

Detoxification

• MicroSilica (IMD)

– Use Intestines NOT Kidneys for Metal Removal

– Insoluble Spheres saturated with strong binding groups

– Binds Mercury in Intestines and moves out of Body

• Stops Enterohepatic Circulation

• Opens Phase III transporters

– Bilirubin levels fall dramatically too!

Saturday, 11 September 2010

Product/System for Intestinal

Detoxification

• MicroSilica (IMD)

– Use Intestines NOT Kidneys for Metal Removal

– Insoluble Spheres saturated with strong binding groups

– Binds Mercury in Intestines and moves out of Body

• Stops Enterohepatic Circulation

• Opens Phase III transporters

– Bilirubin levels fall dramatically too!

• System adds Phytonutrients that enhance Phase II

enzymes and strengthen the vascular system and

Liposomal GSH to raise GSH levels (Phospholipid

Exchange)

Saturday, 11 September 2010

Halbach et al., 2008, Environ Research 107:69-78

A Look at Natural Attenuation Post-

Revision

Saturday, 11 September 2010

Halbach et al., 2008, Environ Research 107:69-78

Changes in RBC Hg after Dental

Revision

No Revision -

MeHg

Revision

Revision-

MeHg

Revision-

HgII

No Revision -

HgII

Saturday, 11 September 2010

MeHg Moving from tissues to

Bloodstream… But NOT Out!

Halbach et al., 2008, Environ Research 107:69-78

Modeled Trend -

Revision

Modeled Trend -

No Revision

Saturday, 11 September 2010

Blood Stream Decrease with

MicroSilica (IMD)

0

0.3750

0.7500

1.1250

1.5000

01/01/08 02/03/08 02/05/08 02/07/08 01/09/08

Blood MeHg (ng/mL)

HgII MeHg

Saturday, 11 September 2010

Blood Stream Decrease with

MicroSilica (IMD)

0

0.3750

0.7500

1.1250

1.5000

01/01/08 02/03/08 02/05/08 02/07/08 01/09/08

Blood MeHg (ng/mL)

HgII MeHg

Saturday, 11 September 2010

Blood Stream Decrease with

MicroSilica (IMD)

0

0.3750

0.7500

1.1250

1.5000

01/01/08 02/03/08 02/05/08 02/07/08 01/09/08

Blood MeHg (ng/mL)

HgII MeHg

Saturday, 11 September 2010

Blood Stream Decrease with

MicroSilica (IMD)

0

0.3750

0.7500

1.1250

1.5000

01/01/08 02/03/08 02/05/08 02/07/08 01/09/08

Blood MeHg (ng/mL)

HgII MeHg

Saturday, 11 September 2010

Blood Stream Decrease with

MicroSilica (IMD)

0

0.3750

0.7500

1.1250

1.5000

01/01/08 02/03/08 02/05/08 02/07/08 01/09/08

Blood MeHg (ng/mL)

HgII MeHg

Depressed Phase II Transferases keep MeHg in

cells; Once they kick in again, enterohepatic

circulation retards excretion from body

Saturday, 11 September 2010

Small Clinical Trial Results

Saturday, 11 September 2010

Effect of Liposomal GSH enhancing

cocktail (Phospholipid Exchange)

Enhancing Both Organ Drainage

and Blood Drainage

Saturday, 11 September 2010

Effect of Liposomal GSH enhancing

cocktail (Phospholipid Exchange)

Liposomal Glutathione

Added to regimen

Enhancing Both Organ Drainage

and Blood Drainage

Saturday, 11 September 2010

Excretion Rates

Liposomal GSH Supplementation

A truly effective chelation based on

the natural detox system!

Saturday, 11 September 2010

Summary

• Retention Toxicity Related to Dysfunction

of Natural Glutathione Detox System, BUT

Affects other detox systems

Saturday, 11 September 2010

Summary

• Retention Toxicity Related to Dysfunction

of Natural Glutathione Detox System, BUT

Affects other detox systems

• Inflamation as major trigger

Saturday, 11 September 2010

Summary

• Retention Toxicity Related to Dysfunction

of Natural Glutathione Detox System, BUT

Affects other detox systems

• Inflamation as major trigger

• MeHg big hidden danger with amalgam

Saturday, 11 September 2010

Summary

• Retention Toxicity Related to Dysfunction

of Natural Glutathione Detox System, BUT

Affects other detox systems

• Inflamation as major trigger

• MeHg big hidden danger with amalgam

• Blood MeHg testing way to monitor detox

Saturday, 11 September 2010

Summary

• Retention Toxicity Related to Dysfunction

of Natural Glutathione Detox System, BUT

Affects other detox systems

• Inflamation as major trigger

• MeHg big hidden danger with amalgam

• Blood MeHg testing way to monitor detox

• IMD safe effective supplement to open up

the detox channels and drain retained

toxicity

Saturday, 11 September 2010

Thank You

Dr. Klinghardt
Saturday, 11 September 2010


A Comprehensive Review of Heavy Metal Detoxification and Clinical Pearls from 30 Years of Medical Practice

by
Dietrich Klinghardt, MD, PhD

Dr Joseph Mercola's Rough Draft Notes from Dr Klinghardt's Presentation at THRiiiVE Summit #5
Daughter 5y.o lost diagnosis - 100 rounds cutler. Aspergers/ autism @2yrs

JeniB
Posts: 5021
Joined: Thu Sep 04, 2008 10:10 pm

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby JeniB » Mon Sep 26, 2011 11:55 am

I wonder how he got rid of the Tapeworm? This has always been in the back of my mind. aren't they hard to treat and find? My son still needs lots of b12 and I wonder if it's a parasite. They love B vitamins don't they?

Is this post, Amanda, from a forum on KPU?
Jen
(mom of 3)

iherb referral code: HOF516
save $5 on first purchase

JeniB
Posts: 5021
Joined: Thu Sep 04, 2008 10:10 pm

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby JeniB » Mon Sep 26, 2011 12:02 pm

A good while back I posted about some info from a guy who used clay to detox the intestines along with AC chelation. He got rid of aluminum very quickly and could move up to 200mg of ALA or more with no reaction, in just a few months time. Mostly because the binding in the gut actually cut down on the kidney's having to do all the work with the blood detox (and thyroid). So, have any of you tried the microsilica or clay? The clay, binds to the mercury in the bile very efficiently this guy said. He was a recovered autistic on some other forum that I had read. He had large amounts of aluminum he was trying to detox, not so much mercury. I've always wondered about binding to more in the gut while chelating. Maybe modified citrus pectin or apple pectin? Something like it? I want more info on the microsilica. is it the same as biosil? silica from horsetail? does silica bind other metals too?
Jen
(mom of 3)

iherb referral code: HOF516
save $5 on first purchase

Pearl1981
Posts: 638
Joined: Sun Jul 17, 2011 7:48 pm

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby Pearl1981 » Mon Sep 26, 2011 6:25 pm

JeniB wrote:I wonder how he got rid of the Tapeworm? This has always been in the back of my mind. aren't they hard to treat and find? My son still needs lots of b12 and I wonder if it's a parasite. They love B vitamins don't they?

Is this post, Amanda, from a forum on KPU?


Jen he said his herb formula quintessence has the most powerful concoction of herbs available and kills every single virus and lyme. Look into it on Bio pure. It is a mix of ayuravedic and traditional chinese medicinal herbs. He studied both ayuraveda and TCM at med school as an extra he was saying in an interview. Herbs kill viruses so well.

He said, as far as I remember, and Im going to look it up now because I actually came online just to do this, after around 9 months on KPU treatment he uses quintessence and plant rizols which kills all lyme and co infections tape worms measles herpes and all the other viruses are poor kids are harbouring in their bodies.
Daughter 5y.o lost diagnosis - 100 rounds cutler. Aspergers/ autism @2yrs

Pearl1981
Posts: 638
Joined: Sun Jul 17, 2011 7:48 pm

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby Pearl1981 » Mon Sep 26, 2011 6:32 pm

Pearl1981 wrote:
JeniB wrote:I wonder how he got rid of the Tapeworm? This has always been in the back of my mind. aren't they hard to treat and find? My son still needs lots of b12 and I wonder if it's a parasite. They love B vitamins don't they?

Is this post, Amanda, from a forum on KPU?


Jen he said his herb formula quintessence has the most powerful concoction of herbs available and kills every single virus and lyme. Look into it on Bio pure. It is a mix of ayuravedic and traditional chinese medicinal herbs. He studied both ayuraveda and TCM at med school as an extra he was saying in an interview. Herbs kill viruses so well.

He said, as far as I remember, and Im going to look it up now because I actually came online just to do this, after around 9 months on KPU treatment he uses quintessence and plant rizols which kills all lyme and co infections tape worms measles herpes and all the other viruses are poor kids are harbouring in their bodies.


One more thing, I think Andy Cutler is correct in his chelation protocol but for that percentage of kids that do not recover on chelation alone - they obviously have some kind of virus problem maybe ...Or need this KPU treatment and then treat the viruses.

Thats why I am combining both treatments, taking the best of both worlds. Nothing wrong with supplementing and giving herbs at the end.

I wanted to add that Andy Cutler does say if chelation is going to work a good difference should be seen fairly soon and after each round. Maybe some kids need extra help with the KPU minerals and herbs to kill those stubborn viruses.

My kid had very bad herpes virus of the gums and tongue Gingivostomatitis. and always had cold viruses too,
Daughter 5y.o lost diagnosis - 100 rounds cutler. Aspergers/ autism @2yrs

JeniB
Posts: 5021
Joined: Thu Sep 04, 2008 10:10 pm

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby JeniB » Wed Sep 28, 2011 11:17 am

Zinc 250mg per day (as Picolinate, Gluconate or Sulfate; liquid is more effective – equals about 1/6th of this as elemental zinc) for 3-4 months. Approximately 3-4mg/kg body weight. Less zinc may be needed later in treatment for maintenance. Nausea after zinc supplementation may be a sign of hypochlorhydria or low stomach acid. This tends to resolve after 2-4 months on the protocol.


http://www.betterhealthguy.com/joomla/i ... e_18-6.pdf

the low stomach acid could be to blame for the nausea. My son isn't getting nausea from the zinc and I think it's because his thiamine levels are up to par. Thiamine makes stomach acid. it's deficiency will cause a decrease in it. Benfothiamine, worked wonders here for digestion. You may also give it at the same time as enzymes with food to see if that helps. Pure Caps has a great zinc gluconate liquid in juice. I was excited to get this form of zinc as it's hard to find.

I personally think that zinc in the gut will do a better job at getting rid of metals there. Have you seen the main ingredient in dandruff shampoo? it's zinc. Zinc directly applied to the area of concern will heal it faster. If that makes sense. If you want to use the cream, we found ourkids zinc/mag cream to work great. They have the zinc alone too I think.
Jen
(mom of 3)

iherb referral code: HOF516
save $5 on first purchase

JeniB
Posts: 5021
Joined: Thu Sep 04, 2008 10:10 pm

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby JeniB » Wed Sep 28, 2011 11:38 am

Monopyrroles are generated
by various bacteria, including
pseudomonas spp.


http://web.mac.com/autismprotocols/Site ... ginnis.pdf

I don't know if anyone has followed my mold posts, but this was mentioned, the bacteria pseudomonas grows in soil treated with types of fungicides used on tobacco and other crops. Well, I think this also grows in the mold from the ground in our area. We live on old farmland. I have a neighborhood full of kids with tinted glasses, tics, autism and more. This is from the mauve factor I found online. Pseudomomnas feeds on copper sulfate, and so do certain resistant molds.

Bacteria can produce this pyrrole seen here. I think this is it for us. The trigger (mold and soil in our area), copper pipes, vaccines and mercury from mom. Cadmium also disabling MT to carry copper out.
Jen
(mom of 3)

iherb referral code: HOF516
save $5 on first purchase

mellowjello
Posts: 1558
Joined: Tue Nov 03, 2009 1:31 am

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby mellowjello » Wed Sep 28, 2011 12:19 pm

JeniB wrote:Thiamine makes stomach acid. it's deficiency will cause a decrease in it.


Thanks for mentioning this, JeniB, this makes sense for us. My daughter has been having increased nausea/vomiting. I had attributed it to low copper which has developed recently, throwing off copper/zinc in a different way, but maybe thiamine is playing a role, too. Her Saccharum dose has been too high and causing aggravations. At the lowest level of Sacc imbalance, she always has symptoms of thiamine deficiency, which has been happening again lately. On top of that, I skipped her multi for a few days. I have restarted it, but it only has 25 mg of thiamine in it.
Learning to jiggle when shaken.

Omamma
Posts: 428
Joined: Tue Mar 21, 2006 11:56 am

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby Omamma » Sat Oct 01, 2011 6:28 am

OK...need to learn to quit bragging so soon! Get a call from the school yesterday. DD's having an explosive meltdown over apparently nothing. The teachers couldn't get her to calm down, so I have to come get her. Really lets the wind outta your sails when things have been going so great, and something like this happens. Once I brought her home she was great all night.
Ugh!
Guess God has more for me to learn.

OneRockAtATime
Posts: 3632
Joined: Mon Mar 19, 2007 2:20 pm

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby OneRockAtATime » Sat Oct 01, 2011 8:26 am

Omamma we are getting similar behavior. He is struggling with Clostridia and it makes it very hard for him to function at school but he does fine at home. Hang in there :)

hyderhari
Posts: 90
Joined: Tue Feb 01, 2011 6:16 pm

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby hyderhari » Wed Oct 05, 2011 11:16 am

Is this the lab everyone uses for the KPU test: www.europeanlaboratory.nl
Please keep me posted.

OneRockAtATime
Posts: 3632
Joined: Mon Mar 19, 2007 2:20 pm

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby OneRockAtATime » Fri Oct 28, 2011 6:42 pm

Help! I am looking for a decent Multi. I have looked around and can't seem to find one that is not crazy expensive or they just aren't decent. I have basically given up the idea that I would get to drop any of the 25+ bottles I am using everyday but really worry that he will get out of wack without some of the regular vitamins I don't give. Any suggestions.

Yes, I posted in this post because the people I think are most likely to know are all posting here.

JeniB
Posts: 5021
Joined: Thu Sep 04, 2008 10:10 pm

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby JeniB » Sat Oct 29, 2011 7:36 am

ORAT, we use individual vitamins here. My son just seemed to always have an issue with something in the ones we tried. This way, I can adjust what he needs day to day. Some days I don't give vitamin A and D (I usually don't give them together either, they cancel out each other) or other fat soluables because of possible toxicity. I like giving lots of B's, C and magnesium. i'm too controlling to use what they pick for me in a multi, it is never the right amount I need for that day and each day changes a sometimes. I used to like Klaire powdered vitamins until I noticed they use kelp for iodine. Most kelp is contamininated with arsenic. I'm sure they have tested and all of that, but just too many different things in there.

I mix mine up in the morning and keep in the fridge in some juice and dose out 3x a day. I like Brainchild's chelate mate for minerals, the best tolerated one's I could find. I also use bodybio's little individual squirt vitamins. I like these to add minerals into the bath and I also use the individual ones to add extra to do our KPU minerals. they are very well absorbed.

sorry I couldn't help. I think Pure Encaps makes some good general multi's. I love their stuff too.
Jen
(mom of 3)

iherb referral code: HOF516
save $5 on first purchase

Cardinal
Posts: 44
Joined: Wed Apr 29, 2009 11:37 am

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby Cardinal » Tue Nov 01, 2011 10:24 pm

OneRockAtATime wrote:Help! I am looking for a decent Multi. I have looked around and can't seem to find one that is not crazy expensive or they just aren't decent. I have basically given up the idea that I would get to drop any of the 25+ bottles I am using everyday but really worry that he will get out of wack without some of the regular vitamins I don't give. Any suggestions.


We use Life Extension Two Per Day Tablets. It's about $7 per month with the iherb discounts.

http://www.iherb.com/Life-Extension-Two ... 24603?at=0

jennylynne
Posts: 1240
Joined: Thu Apr 14, 2011 12:01 am

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby jennylynne » Tue Nov 01, 2011 11:56 pm

We are testing for KPU tonight if she pees enough. So hard to get pee samples from her since she is a wiggler and the urine goes into the diaper.


Crap. I think I may have pylorria. I think I am going to do the test too. And for my YDD. All of us have no morning appetite. I have naseua most mornings..
We all ( even yDD) have some slight nail spots. I have a LOT of stretch marks not from pregnancy. I have acne...even in my 30's. I have tendonitis in every joint, and had knee issues at a child. EVERY one of us has VERY cold hands and feet.

I thought this was caused by thyroid issues...but my thyroid has normalized out over the years and they are still cold. I have adrenal issues as well. What's another deficiency to throw into the pot eh? The kids have no thyroid issues but EVERYONE comments on how cold their extremities are. Very unhealthy hair as well. Even on a standard multivitamin...


I am looking for a mutivitamin as well. Can't find one I like. I may get a joe schmoe kid one and then just add the things ai Need in higher doses....dunno...

mellowjello
Posts: 1558
Joined: Tue Nov 03, 2009 1:31 am

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby mellowjello » Wed Nov 02, 2011 3:17 am

jennylynne wrote:All of us have no morning appetite. I have naseua most mornings...


We were having this with low zinc. I had to give very small quantities (like 5 mg at a time, at first in morning, then higher as day progressed) to get up to the 80 mg she takes a day. If your daughter tolerates more zinc she might need it, and it would explain her reaction to chelation (lack of eye contact, then emotinal withdrawl, less verbal). My daughter's zinc need went up with starting chelation, and getting levels up helped with nausea. Other minerals, too, she needed extra of, and nausea/lack of appetite went away. My daughter and I have both been through this several times (not with DMSA for me, but getting way too low in zinc and having low zinc symptoms and having to catch up) and that's what it is for us anyway.
Learning to jiggle when shaken.

Pearl1981
Posts: 638
Joined: Sun Jul 17, 2011 7:48 pm

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby Pearl1981 » Wed Nov 02, 2011 6:01 am

Jennylynne pee is best taken when child is very stressed. The krptopyrrols are released in urine this way. Freeze them for 12 hours to break up tetropyrrols to kryptopyrrols. Wrap the test in aluminuim foil to avoid the freezer distroying the kryptopyrrols. It is a very delicate proceedure. :) Try to get the specimen to the lab within 12 hours if possible. This gave us a super high test result
Daughter 5y.o lost diagnosis - 100 rounds cutler. Aspergers/ autism @2yrs

amanda NC
Posts: 3037
Joined: Fri May 25, 2007 7:41 am

Re: PLEASE READ--KPU major player in autism; our magic bullet!

Postby amanda NC » Sat Nov 05, 2011 8:17 am

I have guests here, so this will be just a quick update on where we are with our KPU protocol, and how it's working....

My kids are doing GREAT!! Especially my son. There have been NO negatives for him. I will talk about issues that I am having myself, and some with my older daughter, but there has been no sign at all of any of those negatives in him. He is currently only takin 70 mg of zinc daily, and I split that, and will sometimes miss the second half of the dose. I am up to 50 mg zinc now in the morning for him, and as long as he takes it close to breakfast or with breakfast, it does not bother his stomach. Something kind of interesting is that the higher I go with zinc, the better his engagement and language is, and just the overall sense of normalcy. If I miss the second half of the dose for a few days, or miss it altogether, the gains diminish pretty quickly, it seems. Hard to track this with all the infringements at Halloween, and going into the holiday time it will only get worse. I hate this time of year for that reason.

We do the B6 sporadically. I am giving it earlier in the day than recommended. We find that at bedtime it really causes wild dreaming, which disrupts the sleep. I know it's recommended for night, but that hasn't worked for us here. Also, if we take it earlier in the day, we are less likely to have to get up in the night to use the bathroom, another sleep killer. It is either causing oxalate issues or is acting as a diuretic.

This protocol has done really awesome things for my dd11 with anxiety and OCD issues. It has all but resolved them. She is the one who has the hardest time taking supplements, and I have not been as good with them as I'd like; we will continue to work. Her anxiety is nearly gone. We have found that corn RADICALLY increases her anxiety, so we stay away from that still. She is able to do a whole lot of things she wasn't able to before because of anxiety. She is reading better; the adhd issues are going away also. she is only getting 20-30 mg zinc as it is still bothering her stomach, but not nearly as bad as in the beginning.

I am the most interesting case study, I think, as I probably am reacting the way a highly toxic person reacts to the protocol. I'm the kind of person that Klinghardt must have been running into! The protocol makes me feel really good, stipped depression in its tracks, helped my sleep a LOT, my energy also. BUT...I have stopped it because the zinc gives me a SEVERE backache. Debilitating. I had back issues earlier in life, and was supposed to have an operation (lower back) but the pain totally went away when I stopped milk and wheat and joined my kids in the "autism diet". Stopped the inflammation, possibly? Well, the zinc brings it back in spades. It took about 2-3 weeks to start it, but then it was HORRIBLE just overnight. Bam! And now if I take any zinc at all, the ached begins within a day. I tried to ride it out for about 2 months (will have to check the time) but it did not resolve. The B6 makes my bladder HURT. Very sore. Enough to disrupt sleep. And I have to get up the the night to use the bathroom when I take it, even a little of it. So I am trying to find a way to take it anyway...I have added magnesium and that doesn't seem to make a big difference, at least not yet.

My son has come so far that I think I am done. Did I just say that out loud? Oh my. He is just really doing great. I will continue to chelate--we only are doing a round a month--and will continue the protocol, and still are milk and wheat free and preservative free for the most part, and we still have a bunch of supplements I'm not willing to part with, but he is stable, and his energy is good, and all those things I have prayed for.

I want to stress that I have been working on my son for 11-12 years. This is the culmination of a LOT of work with a lot of things, and probably the most important being detoxification. I sit here and wonder, of course, if this was the only problem all along, and if I had known to address this at age 2 1/2, I could have saved a decade of grief. I don't know. But I think it's possible.

Have a good weekend, all!

Hoping you will all keep this on your radar screens.
Amanda, mom of 3


Return to “Diet and Biomedical Treatments for Autism”