Fo2, is your son still on Namenda ? My son is almost 17 and for the last 2 years we have been struggling against violent behaviors, coinciding with adolescence.
I suspected and confirmed that testosterone increases glutamate excitotoxicity (I can find the link if it interests anyone).
From one side there is that Theory of autistics being the super-male, excessive testosterone etc.
From other side, there is the 2012 Bumetanide study, that is still increasing in importance, with double blind/placebo tests being done all over the world, including China, very recently. Excess intracellular chlorine inverting GABA's funtion, from inhibitory to excitatory.
My son is on Bumetanide, and I was thinking if now would it be a good time to try Namenda again.
Only brainstorming: maybe Namenda's effect didn't fix because of excessive chlorine in neurons ? Maybe combining Namenda with Bumetanide could be good ? Maybe trying to reduce testosterone (with inositol and flaxseed powder) could help even more ?
Maybe avoiding supplements that increase glutamate, like B12, and taking others that help to reduce it, like lithium, could help even more ?
I would appreciate others thinking about this (not only Fo2), please.
Maybe we can help each other here exchanging our thoughts.
Namenda caused irritability in my son twice. But everyone is different. Other than that side effect, it was great for social. I wouldn't recommend it though, because I haven't heard of people using it for anger management. My recommendation would be
Verapamil will be on the top of my list due to some parents swearing by its calming properties.
Try Flaxseed oil (anti-androgen).
Try Reishi mushrooms (strong anti-androgen + immune balancing, specifically mentioned its calming properties).
Try Lithium, but ionic. I never tried ionic, but Lithium orotate doesn't work on my son.
Try Manganese to regulate blood sugar levels.
Trileptal was very good for us in balancing the mood.
Talk to psychiatrist about using SSRI for anger off-label. My son just started it. He became very happy and more social boy.