Nikkie111 wrote:This info is very useful!!!! Thank you!
Ok the rs2710102 is a funny one, apparently the GG is the autism allele, the AA is selective mutism or anxiety so different and it's odd cause it doesn't apply to us
Have a look here, there are many SNPs associated with autism but these are the key ones
Admittedly the Rs1858830 is really a dodgy one! But strong antioxidants, antiinflamatory, and antibacterials/diet should sort the issue
Fwiw it can get depressing reading this but I think as long as our issue is not a brain structural thing, it ll be ok
My son has CC mutation in Rs1858830 (MET gene). I ignored it because it is present in 47% of population (http://www.jclinbioinformatics.com/content/2/1/17). But now I am reading that a combination of this mutation and air pollution (specifically polycyclic aromatic hydrocarbon) is what really increases the ASD risk. A detail description of the MET gene function and its implication in autism can be found here: https://passionlessdrone.wordpress.com/2011/02/25/autism-alphabet-soup-met-hgf-plaur-serpine/ IT IS A MUST READ! That post goes through explaining that SNP's are not really dooming and that our bodies always find a way to modify other things to compensate for low or high expressions of SNP genes.
I checked all genes relevant to my son's autism (methylation, detoxification, neurotransmitter, mental, etc). The ones that I think are important are:
rs1801131 MTHFR A1298C (G/G) - occurs in 0.01% population, leads to low BH4 and high ammonia
rs3749034 GAD1 (G/G) - occurs in in 68.6%, rs3828275 GAD1 (T/T) - occurs in 7.5%, both lead to high glutamate levels and seizures
rs6323 MAOA (T/T), rs2270641 SLC18A1 (G/G) - occurs in 13.3%, both lead to high monoamines (norepinephrine, epinephrine, dopamine, and serotonin) and psychiatric disorders, anger
They should guide me in proper selection of supplements (avoid inhibition of MAO-A and GAD, reduce glutamate and ammonia, avoid stimulants and anything that raises dopamine to prevent schizophrenia).