Seeing Good Things With Histidine

Discuss autism diets and biomedical treatments of autism.

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Seeing Good Things With Histidine

Postby MelB1 » Sun Mar 26, 2017 9:32 pm


I am a mom of two nonverbal sons with autism. Both of my boys regressed at 18 months old after antibiotic use for reoccurring infections. I have researched everything I can get my hands on for the past five years especially after we all (myself included) responded favorably to thiamine in the form of B1. But for several years we have only found B1 and Biotin to be of any help after trying just about everything out there. When I run searches on thiamine and autism it keeps bringing me back to this community to posts by a JeniB. It looks like she hasn't been active lately but everything she has posted resonates with our situation. Recently we stumbled upon selenium and the results were better sleep and moods. After several months of supplementing we started showing signs of copper deficiency - kinky hair, reduced energy, elevated histamine etc. I had already read somewhere that selenium could lower copper levels and that a mark of thiamine deficiency was low ceruloplasmin. We had tried to supplement copper in the past but it was disastrous - was clearly becoming biounavailable. We all reacted really badly to even the smallest amounts of zinc. With fear and trembling, because it seemed counterintuitive I started supplementing all of us with 500 mg of histidine and 1 mg of copper. It actually reduced histamine levels and resulted in major cognitive gains! My boys teachers aids at school were freaking out as their learning became accelerated. I'm trying to figure out why nobody seems to know about this for autism. I can't find anything online where someone is doing this. It turns out that histidine and selenium are among the nutrients that make metallothionein. They together are clearly correcting a copper zinc imbalance. Benfotiamine, selenium, and histidine all protect against advanced glycated end products. Copper and selenium are both helpful in addressing hyperthyroidism. Selenium and Culturelle deal with excessive hydrogen peroxide from an overgrowth of Lactobaccillus Acidophilus in the gut which can lead to hyperthyroidism and OCD. I am just trying to figure out if we are like the only individuals in the universe with this biochemical makeup or if there are others who might even know more pieces of the puzzle. Thanks!


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Re: Seeing Good Things With Histidine

Postby Mossy » Wed May 03, 2017 6:08 pm

Thanks MelB1, I had been considering adding Histidine to help with iron usage in our son and I think I'll give it a go as he's generally quite itchy too and it could help crowd out the histamine.

It seems like most kids on the spectrum benefit from zinc, but in some copper or iron deficiency can lead to an adverse reaction from it and other popular treatments like B6.

If you're giving culturelle and have seen stabilisation/progress you might want to try 500mg Omega-3 fish oils (without added vitamins, no Omega 6 or 9) and see if it kicks things on to another level as it could continue the cleanup process. At the very least gives nicer hair :D

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Joined: Fri May 13, 2016 10:55 am

Re: Seeing Good Things With Histidine

Postby Firefly2016 » Sat Jul 08, 2017 12:32 pm

Hello. I am Asperger's (woman/54 years old) and am constantly working on improving my diet and biomedical treatments.

I began a trial of L-Histidine about a month and a half ago. My first day was remarkable. L-Histidine was very calming/soothing to my mind. My notes indicate that I felt happy, relaxed and motivated.

I paired L-Histidine (600 mg/capsule) with Biotin (10 mg/capsule) as I have Partial Biotinidase Deficiency. After a week or two, I added about 250 mcg/capsule Molybdenum. This combination was quite effective for me. It dramatically improved my allergy symptoms....but more importantly my breathing in general. For many years I have had increasing difficulty in travelling to high altitude (above 4-5,000 feet) as well as flying (the interior atmosphere of planes is about 8,000 ft).... But, after taking the above L-Histidine + Biotin + Molybdenum combo, I did a 15-hour flight and did not have any breathing difficulties or headaches (common for me at altitude).

Since my initial trial, I have been taking the L-Histidine + Biotin + Molybdenum combo 2-3 times a day. My response continues to be: my energy improves, my mood lifts, and I just feel cheerier.

I am uncomfortable in taking Molybdenum (at the above dose) long term without finding out how much I have in my body. Additionally, I would like to confirm/deny my genetic status concerning Molybdenum Cofactor Deficiency.

I want to thank everyone on the forum. ... for their warmth, encouragement, and generosity in sharing information.


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