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Re: My supplement/drug list for ASD

Posted: Sun Apr 23, 2017 2:47 pm
by luis
Fo2, I also think that aggressions are related to hypoglycemia episodes. I am struggling to get it under control.

Re: My supplement/drug list for ASD

Posted: Wed May 03, 2017 6:03 pm
by Mossy
FatherOf2 wrote:
TravonMom wrote:Thanks....One more thing can you share the link where you ordered the Piracetam? I thought I wrote it down but I can't find it now

https://supplements.relentlessimprovement.com/piracetam-p240.aspx?widget=mp

If you are outside US, try to get the branded Nootropil manufactured in UK

f
Be very careful with piracetam, particularly being careful to take it with choline as you may get a raging kid or foggy kid otherwise. For example see here: https://selfhacked.com/2013/07/17/why-i ... piracetam/ (note most of these cases are with the self hacking crowd who take far higher doses than normal).

In general GABA-analogues work fantastically for some, but can be adverse in a few. I'd make sure you really get a solid understanding of your kids GABA (A and B) function and how these nootropics work before using them.

One interesting compound in the self hacking world that oddly isn't in the ASD one is Phenibut, another GABA analogue. This outperforms even prescription drugs but can build dependence if you're not careful. Saving this for if other treatments fail for our son.

Re: My supplement/drug list for ASD

Posted: Fri May 05, 2017 3:46 pm
by Bm1
Father0f2 great list! Interesting to see creatine bcos we suspect a creatine deficiency in our child too...did you do tests to see if there was a deficiency...or did you supplement on your own...we currently supplement a bit of creatine HCL (more bioavailable than monohydrate) as part of our mito cocktail.

Re: My supplement/drug list for ASD

Posted: Sun May 07, 2017 2:16 am
by FatherOf2
Bm1 wrote:Father0f2 great list! Interesting to see creatine bcos we suspect a creatine deficiency in our child too...did you do tests to see if there was a deficiency...or did you supplement on your own...we currently supplement a bit of creatine HCL (more bioavailable than monohydrate) as part of our mito cocktail.

No, we didn't test for creatine. I started it because it was listed in Deprtment of Defence (DoD) research as one of the most effective supplements for brain injury in soldiers. I first tried Con-Cret. While I saw great gains the same day (his ABA therapists said that she never saw him so high-functioning), he was very irritable. I stopped after a couple of days. Then, following advice from this forum, I tried Kre-Alkalyn, 1 capsule (750mg) in am. I saw the same gains, but no irritability. My son has been on it for 1 month, and it has been a very good month. Last week was the best week in the last 6-8 months thanks to adding Quercetin. We also started Flaxseed oil. I don't know if it is Flaxseed oil or Quercetin, but my son is much calmer this last week, doing less hand/visual stimming, more aware, and better cognition. He is in 2nd grade (8yo). For example, before last last week, if asked how much 70 + 8, he would start adding ones: 70 + 1 = 72, 70 + 2 = 72, and so on until he gets to 70 + 8 = 78. He just didn't get it. But last two days, when asked 50 + 7, he would immediately say 57. Also, on Friday, his school aide was out and replaced with a substitute. Without any prompts or hints, he saw a new person in class, approached her and asked if she was a substitute and whether his previous aide was sick. I saw it myself and was very impressed. I am 'blaming' Quercetin, but all three Creatine + Quercetine + Flaxseed oil go into my hall of fame.

Re: My supplement/drug list for ASD

Posted: Mon May 08, 2017 9:37 am
by Mossy
Why give flaxseed oil rather than fish/krill oil for Omega 3? Seems extra step of converting from ALA to DHA etc doesn't have much upside?

Re: My supplement/drug list for ASD

Posted: Mon May 08, 2017 2:18 pm
by FatherOf2
Only small amount of alpha linolenic acid is converted to DHA and EPA. The rest is doing its own thing such us suppressing PERK/eIF2a signaling. You can search for my earlier topic here regarding ALA and PERK. Also internet. Fish oil may be doing the same thing, but so far hasnt been reported.

Re: My supplement/drug list for ASD

Posted: Tue May 09, 2017 1:28 am
by FatherOf2
Mossy, read here about ALA and PERK/eIF2a signaling: http://www.elabscience.com/Manual/wenzhang/124.pdf
"As a nutritionally essential PUFA, α-linolenic acid (ALA, 18:3 n-3) can act as the precursor of longer chain n-3 PUFA (docosahexaenoic acid (DHA, 22:6 n-3) and eicosapentaenoic acid (EPA, 20:5 n-3) or compete with linoleic acid to reduce arachidonic acid content or direct interaction with ion channels and nuclear receptors, and thus may exert numerous beneficial effects in human body, such as anti-oxidative, anti-inflammatory and neuroprotective functions as well as accelerating brain growth in preterm and neonates (Kim et al., 2014). To date, the merit given to ALA is largely due to its conversion to DHA and/or EPA, and studies focus on the neuroprotective efficacies of ALA per se are limited..."

Also about importance of PERK/eIFa signaling in AS here: http://www.nextbigfuture.com/2017/04/anti-dementia-drugs-will-soon-start-clinical-trials.html

Re: My supplement/drug list for ASD

Posted: Tue May 09, 2017 10:53 am
by Mossy
Thanks Fatherof2, giving DHA/EPA at hte moment which help with apraxia but will consider it.

What time of day do you give the Kre-Alkalyn out of curiousity? Considering trying it out, giving most supplements in the night before sleep now except galantamine in the morning.

Re: My supplement/drug list for ASD

Posted: Tue May 09, 2017 11:57 am
by FatherOf2
I give it in the morning. I give most of my supplements in am except for Taurine anf flaxseed oil, both of which help with sleep.

Re: My supplement/drug list for ASD

Posted: Fri May 12, 2017 2:47 pm
by don_long
Where I can buy Piracetam with shipping outside US?

FatherOf2 wrote:
TravonMom wrote:Thanks....One more thing can you share the link where you ordered the Piracetam? I thought I wrote it down but I can't find it now

https://supplements.relentlessimprovement.com/piracetam-p240.aspx?widget=mp

If you are outside US, try to get the branded Nootropil manufactured in UK

Re: My supplement/drug list for ASD

Posted: Sat May 13, 2017 1:24 am
by FatherOf2
don_long wrote:Where I can buy Piracetam with shipping outside US?

Check some Canadian pharmacies: https://www.pharmacychecker.com/brand/price-comparison/nootropil/800+mg/

Re: My supplement/drug list for ASD

Posted: Mon May 15, 2017 12:54 pm
by Mossy
Which Krill Oil are you using? Seem to be a number of different blends, such as this one: https://www.amazon.co.uk/Omega-Krill-Oi ... hin+1000mg

Looking at adding straight Astaxanthin at 6mg dosage levels, seems a pretty powerful antitoxidant

Re: My supplement/drug list for ASD

Posted: Mon May 15, 2017 2:08 pm
by FatherOf2
Antarctic Krill oil, Superba 2, packaged by Sports Research

There are only two companies in the world making Krill oil. The one above from Norway and Neptune Krill Oil from Canada. All other brands like Sports Research use either of those two. The one that you linked is NKO from Canada.
My current list of supplements that I give to my son together with brands and doses is at the end of my first post.

Re: My supplement/drug list for ASD

Posted: Sat Jul 08, 2017 6:36 am
by Hanuviji
FatherOf2 wrote:This is a summary of supplements and drugs that I researched and/or tried to help with various symptoms of ASD. Those that had profound positive effect on my autistic son are marked in red. I placed drugs at the end of each section. My current list of supplements is at the end of this post, under the green title. I intend to update the full list and add new sections (hopefully this first post will stay editable). I invite other parents to report their experiences to help others to quickly find a treatment for specific symptoms. I will add other parents recommendations to this list.

Abnormal EEG and seizures (regressive autism is often caused by abnormal EEG activity)
    MCT oil (also kills yeast, can cause anger)
    Vit B6 (causes anger due to MAO)
    Mg (Epsom salt baths are best)
    DMG (inhibits conversion of homocysteine to methionine and SAMe, known to cause anger and SIB)
    Taurine (500mg before bed, helps with sleep, treats mania, better not to discontinue abruptly to avoid seizures)
    Carnosine (causes anger probably because it inhibits DAO, which breaks down histamine)
    Vit E (α-tocopherol)
    Selenium
    Bacopa (slightly better behaviors)
    Vinpocetine
    Bupleurum Chinense
    Frankincense oil
    Vit D
    Trileptal (reduces SIB, side effect: reduces calcium, that is why I use a small dose of 150mg 2x/day)
    Lamictal (Na-channel blocker, also facilitates GABA release and reduces presynaptic release of glutamate, increases socialization and speech, but can cause Stevens-Johnson syndrome)
    Valproic Acid (negatively affects cognition)
    Keppra (beware of 'Keppra rage')
    Gabapentin (claimed by some MAPS doctors to help with speech and reduce stims)
    Prednisone (corticosteroid, those who tried it report amazing results including speech for the first time, but cannot be taken long term)
Avoid: Coffeine (coffee, black or green tea), Aspartame, Tyrosine, Ginkgo Biloba, Ginseng, Sage, Goldenseal/berberine, Starflower/borage, St. John's Wort, Uva Ursi, Kava Kava, Yohimbe, Colloidal silver, Copper, ADHD drugs
Caution: Melatonin may increase or decrease seizure activity
Caution: There is a conflicting info on Creatine and seizures. Medical journals write that it actually reduces seizures whereas rare single cases report seizures from it. It is not clear whether seizures while taking Creatine were due to Creatine (high dose?) or exhaustion from exercise (Creatine is a popular supplement among bodybuilders).
Caution: Grapefruit juice and niacin may interact with Tegretol (carbamazepine)

Psychosis and mania (schizophrenia is sometimes diagnosed as ASD in young patients):
    Fish oil (anti-inflammatory, balances dopamine at D1 and D2 receptors)
    Arachidonic Acid (low activity of ARA can cause ASD and schizophrenia symptoms; fish oil should be supplemented together with ARA)
    Glycine & D Serine (full agonists of NMDA receptors, which are low functioning in schizophrenic patients; Glycine and D Serine give comprehensive improvement in SZ symptoms; Glycine is also inhibitory and should be given at night, D Serine may cause seziures while Glycine may reduces them)
    Sarcosine (can be even more effective than Glycine or D Serine thanks to blocking reuptake of glycine through GlyT1; showed week anti-convulsant properties; DMG is metabolized into Sarcosine)
    NAC (reduces glutamate, often combined with Sarcosine for greater effect))
    B3 + vit C (B3 raises blood sugar)
    Lithium (ionic, lithium orotate never worked for my son)
    BCAA (treats mania)
    Choline (phosphatidyl choline, reduces mania)
    Bupleurum Chinense (D2 blocker)
    Reserpine (blocks VMAT2 and less VMAT1)
    Sodium benzoate (food preservative, inhibits DAO, binds and excretes amino acids reducing ammonia levels, may form carcinogen benzene)
    Risperidone (blocks receptors responsible for schizophrenia symptoms such as D2, inhibits DAO, can cause seizures)
    Abilify (less side effects than Risperidone)
    Clozapine (partial antagonist at 5-HT2A, GABAB agonist, induces release of glutamate and D-serine, can cause seizures)
Avoid: Sugar, Tyrosine, Phenylalanine, B6 (converts L-Dopa to dopamine), Zinc (DA re-uptake inhibitor), Evening Primrose (increases dopamine, but also modestly helps schizophrenics due to conversion to prostaglandin E1, which is low in schizophrenics), Chinese Skullcap (DA re-uptake inhibitor), ADHD drugs like Ritalin and Focalin, SAM-e (can induce mania in bipolar patients), D-Cycloserine (partial agonist of NMDA receptors, which acts as antagonist when combined with high levels of agonist, worsening the psychosis).
For MAO mutation avoid: Tyrosine, Tryptophan, Phenylalanine, Spirulina, B6, Zinc

Anger, aggression & self-injurious behavior:
    Eating small meals throughout a day at the same times (to avoid low blood sugar levels)
    EPA-rich fish oil (2-3g, helps to control anger and aggression possibly due to its dopamine and glucose regulation properties)
    Flaxseed oil (anti-androgen)
    Manganese (regulates blood sugar, many hypoglycemia patients swear by it)
    Mg (calming, Epsom salt baths are best, MagMind is also good but I never saw visible effects)
    Lithium (ionic, lithium orotate never worked for my son)
    Reishi (anti-androgen, immune balancing, calming)
    Nicotine patches (calming, reduce SIB, some evidence to help Alzheimer's patients)
    Tennex (reduces impulsivity but can cause drowsiness)
    Verapamil (hypertension drug, Calcium channel blocker, stops anger rages and SIB, off-label used for bipolar disorder)
    Propanolol (another hypertension drug, beta blocker, used to treat anxiety and anger off-label, it improved verbal skills in ASD studies)
    SSRI's (used commonly for depression but also at low doses for anger management off-label)
    Riluzole (blocks glutamate transmission and reuptake of GABA, significantly reduced irritability in trials, increases appetite and weight)
    Spironolactone (aldosterone antagonist and potassium-sparing diuretic, reduces inflammation, lowers testosterone and aggression)
    Low Dose Naltrexone (reduces hyperactivity and SIB, can be taken orally or as cream, affects sleep for the first 2 weeks)
    Trileptal (reduces SIB, also AED, side effect: reduces calcium, that is why I use a small dose of 150mg 2x/day)
    Abilify (less side effects than Risperdal)
    Immune Boosters (GcMAF and Actos are reported by some to reduce meltdowns)
Avoid: anything that increases dopamine such as Sugar, dopamine precursor Tyrosine, another dopamine precursor Phenylalanine, chocolate (contains sugar, Tyrosine and Phenylalanine), B6 (converts L-Dopa to dopamine), Zinc (DA re-uptake inhibitor), Evening Primrose, Chinese Skullcap (DA re-uptake inhibitor), ADHD drugs like Ritalin and Focalin (contain meth, which is DA re-uptake inhibitor).
Avoid: MAO inhibitors such as B6, Zinc, many herbs such as Curcumin
Avoid: Anything that reduces blood sugar: alpha-lipoic acid/ALA, Cinnamon, Curcumin, Ginger, Berberine/Goldenseal, Elderberry, Chamomile, Chinese Skullcap even though it is sometimes used for anger-management, Fenugreek, Stinging Nettle, Gymnema, Aloe, Resveratrol (grape seed extract), most adaptogenic herbs such as Ashwagandha and Ginseng, Chromium, Vanadium, SAMe. Chelation leads to adrenal fatigue, low cortisol and blood sugar levels. It caused extreme defiance in my son that lasted 1.5-2 months after each of the last 3 rounds. Adrenal support supplements didn't help.

Poor focus, memory & cognition:
    Krill oil (contains EPA and DHA bonded with phospholipids - mostly phosphatidylcholine, so you get both Omega 3 and PC)
    Choline (Citicoline or Alpha GPC, increases acetylcholine in the brain, boosts ATP by 14%, much milder effect than Galantamine)
    Phosphatidylserine (no visible effect on cognition, supposed to stabilize cortisol and mood, but we haven't noticed that, causes stims)
    Idebenone (synthetic CoQ10, increases NGF and connectivity between left and right cerebral hemispheres, stimulates synthesis of ATP, currently awaiting FDA approval for treatment of Duchenne Muscular Dystrophy, start with 30mg)
    D Serine (co-agonist of NMDA receptors, enhances cognition in schizophrenia patients, important if DAOA is mutated)
    Carnosine (slightly better cognition, but causes anger probably because it inhibits DAO, which breaks down histamine)
    Creatine (strong effect on cognition & speech, but can cause irritability and SIB possibly due to hypoglycemia, better form is Kre-Alkalyn)
    NADH (active form of B3, with vit C recycles glutathione, increases BH4 & ATP in brain, good supplement for MTHFR A1298C mutation)
    Biotin (in high does of 300mg enhances myelin production and reduces axonal hypoxia through enhanced energy production, used by Multiple Sclerosis patients)
    L-Theanine (can cause mood swings, often combined with Caffeine)
    Iron (iron deficiency can cause ADHD)
    Pycnogenol (no visible effect)
    Bacopa (also anti-seizure, slightly better behaviors, often combined with Panax Ginseng and Rhodiola Rosea)
    Vinpocetine (promotes blood circulation, anti-seizure, no visible effect)
    Gingko Biloba (promotes blood circulation, but may cause seizures)
    Chinese Skullcap (liver toxicity? can cause behaviors as DA re-uptake inhibitor)
    Lion's Mane mushrooms (anti-oxidant, regenerates nerves)
    HBOT (can cause seizures if EEG is abnormal - start AED first, can also cause yeast overgrowth - take Ampho B)
    Leucovorin Calcium (folinic acid, increases hyperactivity, causes anger)
    Piracetam (cyclic derivative of GABA, helped with speech, studied in autistic children, not approved in USA)
    Galantamine (acetylcholinesterase inhibitor, start with 1mg am, effect lasts 2-4 weeks, then either increase dose or cycle On/OFF, may increase seizures in rare cases)
    Huperzine A (another acetylcholinesterase inhibitor, also blocks NMDA, which helps to prevent NMDA-induced seizures)
    Namenda (NMDA receptor blocker, a 'better magnesium', helped with socialization, but led to higher irritability)
    Vayarin (Phosphatidylserine conjugated with Omega 3 EPA and some DHA, it didn't help my son, but some parents report improvements)
    ADHD stimulant drugs Ritalin, Focalin, Adderall, Vyvanse (based on meth and can cause addiction, Schedule II, may cause tics, reduce appetite, carry FDA warning of possibly triggering schizophrenia in predisposed patients due to their dopamine reuptake inhibition)
    Modafinil/Provigil (weak dopamine reuptake inhibitor, studied on children, classified as a schedule IV drug due to its lower addiction potential than other ADHD drugs, may lead to psychosis due to being a partial agonist of D2 receptors, but overall is much safer than other ADHD drugs)

Brain inflammation and oxidative stress (cause glutamate toxicity, seizures, etc):
    Fish Oil (there are some claims that Krill oil is better for inflammation due to higher bioavailibity of EPA and DHA, which are bonded with phospholipids - mostly phosphatidylcholine, so you get both Omega 3 and PC)
    Evening primrose oil (source of GLA)
    Vitamin E + selenium (vit E as Jarrow's Toco-Sorb)
    Vitamin D (anti-inflammatory)
    Vitamin C
    CoEnzyme Q10 (combine with B2)
    Melatonin (1-3mg before bed, helps to fall asleep, not as effective as Taurine in keeping asleep through the whole night)
    NAC (precursor of glutathione, reduces glutamate, but not recommended for long term, can cause yeast overgrowth)
    Alpha-Lipoic Acid or ALA (anti-oxidant, used for chelation, must be careful with dosing, can cause irritability, yeast overgrowth)
    Resveratrol (anti-oxidant, tips glutamate/GABA balance towards GABA, anticonvulsant add-on)
    Cocoa flavanols (anti-oxidant, enhances cortical blood flow, contains DA precursors Tyrosine and Phenylalanine, which can lead to anger)
    Quercetin or Luteolin (antioxidants, block release of glutamate, but can cause irritability due to MAO inhibition, Quercetin had more pronounced effect than Luteolin and didn't cause irritability)
    Sulforaphane (broccoli sprouts extract, no visible effect on my son, seizures is a possible side effect)
    Pycnogenol (anti-oxidant, improves cognition, but we saw no effect)
    Cat's Claw
    Green tea and EGCG
    Turmeric/Curcumin (contains sulfur, inhibits MAO, can increase irritability like in my son)
    Boswellia (as Frankincense oil)
    Lion's Mane mushrooms (anti-oxidant, regenerates nerves, improves cognition)
    Ibuprofen (COX-2 NSAID, typically cycled 1 month on, 1 month off, need support for gut health)
    Celecoxib (another COX-2 NSAID, in studies reduced irritability, long-term use causes GI problems)
    Singulair (lieukotriene inhibitor, zero effect on my son)
    Ketotifen (old allergy drug, noncompetitive H1-antihistamine and mast cell stabilizer, some claim to be very effective)
    Glutathione (delivery is a problem, doesn't absorb orally, creams seem ineffective, never tried nasal sprays, IV push works)
    Spironolactone (aldosterone antagonist and potassium-sparing diuretic, reduces inflammation, lowers testosterone and aggression)
    Prednisone (corticosteroid, those who tried it report amazing results including speech for the first time, but cannot be taken long term, suppresses immune system)
    DMSA & DMPS (chelators but also anti-oxidants, can cause irritability, yeast overgrowth)
Avoid: Stress (inflammation is an early stage of the stress response), poor sleep (increases IL-6), dehydration, sugar and fructose (raise inflammation markers IL-6 and CRP, affect calcium metabolism, and deplete B vitamins), pasteurized, homogenized and otherwise cooked diary products (omega-3 fatty acids are destroyed), trans fats (french fries, potato chips, trans fats inhibit omega-3 metabolism), foods high in omega-6 such as corn (corn syrup is added to almost everything, high fructose corn syrup is the worst, need to balance with omega-3), foods high in MSG, red meat (high in iron, also contains Neu5Gc, which triggers inflammation response), oxidizing minerals (three 'amigos' aluminum, manganese and iron, also high-dose chromium, high-dose selenium), sodium/potassium ratio above 5 or less than 2, calcium/magnesium ratio greater than 10 (especially if combined with a high sodium/potassium ratio), seafood rich in mercury (tuna, shellfish, swordfish, but sardines are OK). untreated PANDAS or Lyme disease, GI infections (candida albicans, clostridia), chlorine and fluoride in tap water, smoking, alcohol, non-steroidal anti-inflammatory drugs such as Tylenol or Aleve, coffee, stimulant ADHD drugs, allergens (casein, gluten, pollen, dust, mold).

Allergies (this could be a single reason for autism in some cases, mast cell activation causes brain fog):
    GFCF diet (if allergies to casein and gluten)
    Cromolyn (stabilizes mast cells, used mostly for acute treatment)
    Quercetin (stabilizes mast cells & reduces CRH hormone that stresses adrenal glands; often taken with Bromelain, which improves absorption; Quercetin is more potent than Cromolyn)
    Forskolin (mast cell stabilizer)
    EGCG (from green tea, inhibits histidine conversion to histamine and stabilizes mast cells, like Quercetin it inhibits IL-6)
    Reishi mushrooms (stabilize mast cells, shift immune balance away from fighting allergies)
    Astragalus (stabilizes mast cells, nourishes the adrenal glands, which is important because histamine burns out the adrenal glands that work to keep inflammation in check)
    Gamma-Linolenic Acid (many take fish oil/omega 3 without supplementing omega 6, but both should be taken together; LA and AA tend to promote inflammation, but GLA may actually reduce inflammation; preferred source of GLA is EPO)
    Copper (required to form DAO enzyme, which breaks down histamine; Cu is also used by MAO anzyme that breaks down dopamine and serotonin; large intake of zinc reduces copper)
    Benadryl (activates DAO, take before bed)
    Minocycline (antibiotic, but often used to reduce microglial activation that plays a role in chronic neurological inflammation; reduces overall levels of IgE)

Anxiety, OCD, poor eye contact, stims, other sensory and social issues
    GFCF diet (even though my son is allergic to milk according to blood test, GFCF didn't help, neither did antihistamines)
    B-Complex (especially B3 and B12, B3 helps to reduce anxiety, but in high doses stresses liver, combine with equal or higher dose of vit C)
    Arachidonic Acid (low activity of ARA can cause ASD and schizophrenia symptoms; supplementing with ARA reduces repetitive and addictive behaviors and increases social interactions)
    Inositol (IP6 Gold)
    NAC (precursor of glutathione, provides cysteine to bind glutamate, reduces OCD and stims)
    Magnesium + Calcium (I got rid of my panic attacks by drinking milk before bed)
    L-Theanine (can cause mood swings)
    Tryptophan (increases serotonin, reduces anxiety, helps with sleep)
    Quercetin (reduces excess stress hormone corticosterone thus causing an anti-anxiety effect comparable to prescribed drugs)
    Rhodiola Rosea (second most popular adaptogen after panax ginseng, reduces fatigue, increases serotonin and improves mood, reduces corticosteroids and anger, increases focus, can inhibit MAO-A but perhaps not when taken orally, better if cycled 4 weeks on/2 weeks off)
    Honokiol (a phytochemical from Magnolia bark, reduces anxiety by modulating GABA_A receptors, has a comparatively lower risk of causing benzodiazepine-like side effects, such as central depression, muscle relaxation, amnesia, or physical dependence)
    Oxytocin nasal spray (increases socialization)
    R-Baclofen (GABA_B agonist, improves communication and socialization, stabilizes EEG, suppresses PERK/eIF2α signaling responsible for dementia)
    Riluzole (blocks glutamate transmission and reuptake of GABA, reduces OCD, anxiety and irritability, increases appetite and weight)
    Namenda/Memantine (blocks NMDA receptors, reduces OCD and stimming)
    Propranolol (hypertension drug, beta blocker, used to treat anxiety and anger off-label, it improved verbal skills in ASD studies)
    Clonazepam (only tiny non-sedating doses, to treat seizures and panic disorder)
    Celexa and other SSRI's (SSRI's are the key ASD treatment of Dr. Goldberg)
    Chelation (claimed to eliminate many ASD symptoms including stims)

Yeast overgrowth (giggling, goofiness, spinning, stims, fluffy sponge-like poop)
    Probiotics
    Candidase or Candex enzymes (Cellulase and Protease, can cause stomach pain, takes about 4-6 weeks to see results, I never saw anything)
    Biotin (never saw any effect)
    MCT Oil/Caprylic Acid
    Grapefruit Seed Extract/GSE or GFSE (Nutribiotic drops,contains phenols, slows down liver metabolism, use only for 1 week)
    Berberine/Goldenseal (sensitizes neurons to glutamate, inhibits MAO-A, don't use longer than 2 weeks, my son is more aware on it, but eventually develops irritability)
    Garlic (sometimes is added to antifungal enzymes)
    Uva Ursi (can cause seizures and serious liver damage)
    Nystatin (broad spectrum but weak, safe)
    Amphotericin B (my favorite, broad spectrum, very effective and safe if used orally, sold only through compounding pharmacies)
    Diflucan/Fluconazole (because this drug doesn't kill all yeasts and is toxic to liver, only use it if you detected a yeast that this drug kills)
    Ketoconazole (very effective against many yeasts, a 'big gun', toxic to liver)
Avoid: Sugar and and high sugar fruits and juices, carbohydrates, sulfur-based supplements like ALA, NAC, Curcumin, chelating drugs

Bacterial infections (cause poor eye contact, tantrums, aggression, SIB)
    Garlic
    Echinacea (often combined with Goldenseal)
    Berberine/Goldenseal (sensitizes neurons to glutamate, may reduce seizure threshold, inhibits MAO-A, don't use longer than 2 weeks, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107129, my son is more aware on it, but eventually develops irritability)
    Turmeric/Curcumin
    Oil of Oregano
    Flagyl/Metronidazole (most popular add-on of anti-fungal protocols)
    Vancomycin (popular add-on of anti-fungal protocols)
    Alinia (antibiotic and anti-parasite)
Avoid: Colloidal silver. Silver doesn't belong in the body and cannot be excreted, leading to its accumulation and argyria disease.

Viral infection (poor eye contact, tantrums, aggression)
    L-Lysine
    Lauricidin (tastes like soap)
    Elderberry
    Echinacea
    Astragalus
    Cat's Claw
    Olive leaf extract
    Licorice root
    Virastop enzyme
    Valtrex (effective for Herpes family but not RNA viruses like measles and rubella)
    Amantadine (also NMDA antagonist, reduces irritability, hyperactivity and OCD, helps with ADHD)
    Immunovir (immunostimulant, used to treat measles, herpes, wards)
Avoid: Arginine - feeds herpes virus

Immune system dysregulation
    Fish oil (most likely suppresses immune system due to evidence of fish oil increasing prostate cancer risks)
    Evening Primrose Oil (possibly suppresses immune system)
    Castor oil (boosts immune system)
    Vitamin C (if taken before cancer, prevents it; if taken during cancer, promotes it)
    Vitamin D3 (activates immune system)
    B12 (boosts immune system)
    Probiotics (cancer fighting Lactobacillus acidophilus, L bulgaricus, and L casei)
    Zinc (activates immune system)
    Colostrum
    'Hamlet' breast milk compound (just recently discovered in Sweden as a very effective anti-cancer compound)
    DIM/Diindolylmethane (a substance found in cruciferous vegetables, reduces estrogen, anti-cancer)
    Indole-3-carbinol (a substance found in cruciferous vegetables, anti-cancer, fight viruses, detox body)
    Salvestrol (produced by plants in response to fungal infection, used in humans to fight cancers)
    MGN-3/Biobran (complex sugar derived from rice bran treated with extracts from three mushrooms: Shiitake, Coriolus versicolor, and Suehirotake, stimulates immune system)
    IVIG (very powerful but controversial, can bring allergies that didn't exist before depending on the blood donor)
    GcMAF (modified vit D-binding protein, has been promoted as a cure for cancer, HIV, autism, and other conditions, not approved in USA)
    Low-Dose Naltrexone (transdermal once daily between 9pm and 12 am, can disrupt sleep for the first 2 weeks)
    Actos (shifts immune balance from predominant T2 humoral immunity to T1 cellular immunity, improves cognition, calmness, verbal ability, and socialization, reduces aggression)

Toxins, heavy metals
    Chlorella
    Modified citrus pectin
    Vit C (some say it chelates lead at large doses)
    Selenium (co-factor of glutathion production, often combined with vit E and C, Se also has strong binding affinity to mercury, Hg – Se is not absorbed and gets flushed out)
    Sauna (sweating removes toxins)
    Bentonite Clay baths (beware that Bentonite clay contains lead and carries Prop 65 warning in California)
    Glutathione (not absorbed orally, use sublingual, nasal, transdermal or IV push)
    NAC (precursor to glutathione - key detoxifier, combine with Glycine and Mg for more GSH)
    Alpha Lipoic Acid/ALA (antioxidant, neutralizes several toxins including heavy metals, acts as a co-enzyme for recycling glutathione, key supplement in Andy Cutler mercury chelation protocol)
    Milk Thistle (contains Silymarin, protects liver by boosting glutathione)
    Melatonin (hormone known to regulate sleep, also a powerful antioxidant raising glutathione levels)
    Chelation with DMSA, DMPSA, EDTA (can cause irritability)
Avoid: Fish with low selenium relative to mercury such as pilot whale, shark, tilefish, shellfish (particularly mussels and scallops), king mackerel, marlin and swordfish.
Avoid: Eating liver and kidney of animals, rice (there was a study showing that those on GF diet tend to consume more rice products, which are rich in lead and arsenic, causing more harm than gluten), oily seeds, cocoa powder (high lead), raw tea (high lead, ready to drink teas have less lead), dried seaweed (one of the most contaminated foods), dried leaf vegetables or dried mushrooms or dried edible plants or dried herbs (high lead).
Caution: Dietary supplements including herbal extracts have the highest amount of lead, cadmium and arsenic measured in mg/kg (or ppm) among all foods. My advise is to be very selective. See "Food Safety – Heavy Metals in Foodstuffs" reports from USDA.

Non-verbal, delays in expressive and receptive language
    iPad (flashcards and other speech programs)
    Listening therapies (Tomatis, ILS, etc)
    GFCF diet and removal of allergens (even though my son is allergic to milk according to blood test, GFCF didn't help, neither did antihistamines)
    Krill Oil (contains EPA and DHA bonded with phospholipids - mostly phosphatidylcholine, so you get both Omega 3 and PC)
    SPEAK = 725mg EPA + 275mg DHA + 200mg gamma tocopherol + 500IU d-alpha tocopherol + 60mg GLA + 800IU D3 + 1mg K1 + 150mcg K2
    MB12 shots (we had no luck with MB12 or Hydroxy B12 but most other parents report good results)
    B6 + Mg (the most commonly given combo to ASD kids around the globe, B6 can cause higher irritability in presence of MAO mutation)
    DMG (was the very first supplement we tried, it helped my son to start communicating with us through touch, but also caused head banging, which stayed for years even after discontinuation of DMG)
    TMG (TMG activates BHMT pathway of converting homocysteine into methionine and SAMe whereas DMG inhibits BHMT, hard to say if it did anything)
    Acetyl-L-Carnitine (didn't do anything for my son but supposed to help with receptive language)
    Carnosine (zero effect on my son except higher irritability due to DAO inhibition and higher histamine)
    Quercetin (my son is doing great on it, more present, more social, speaks more, happier)
    Creatine (adding it on my own due to impressive results https://www.ncbi.nlm.nih.gov/pubmed/20159424, better form is Kre-Alkalyn)
    Cytoflora
    Antifungal therapy (antifungal + antibiotic, commony used by MAPS doctors, but, in my opinion, it is ineffective)
    HBOT (moved my son to functionally new levels in his development)
    Piracetam (cyclic derivative of GABA, helped with speech, studied in autistic children, not approved in USA)
    Prednisone
    Anti-seizure meds (Lamictal, Trileptal, Keppra, Valproic Acid)
    BH4 (for those with MTHFR A1298C mutation which affects production of dopamine and serotonin; I never tried; sold as very expensive drug Kuvan)
    Chelation (controversial)


CURRENT LIST OF SUPPLEMENTS (6/16/2017):
AM:
    Antarctic Krill Oil with Astaxanthin (1000mg, contains EPA and DHA bonded with PC, helps with speech & focus)
    Vayarin (also helps with focus)
    Doctors Best Fully Active B complex (no visible effect)
    Jarrow Toco-Sorb (mixed Tocotrienols and vit E, supposed to reduce seizures, no visible effect)
    Selenium (200mcg, works with vit E, removes mercury, no visible effect)
    MRM Quercetin QU995 (500mg, reduces histamine, helps with awareness)
    Kre-Alkalyn Creatine (750mg, helps with awareness and muscles)
    Natural Factors Vitamin C Tangy Orange (500mg, chewable, the only vit C that my son likes, no visible effect)
    Potassium (100mg, needed to supplement with Bumetanide, see below)
    Fiber Choice Inulin (2 gummies, according to Nemecheck protocol, I think it makes my son calmer)
    Rx meds: Trileptal (150mg, stabilizes EEG, reduces SIB), Lamictal (50mg, stabilizes EEG, helps with social), Bumetanide (0.5mg, helps with social)
PM:
    Taurine (500mg, helps with sleep, stabilzes EEG)
    Flaxseed Oil (supplies alpha linolenic acid that suppresses immune PERK/eIF2a signaling, which blocks protein synthesis in the brain)
    Fiber Choice Inulin (2 gummies, according to Nemecheck protocol, I think it makes my son calmer)
    Rx meds: Trileptal (150mg, stabilizes EEG, reduces SIB), Lamictal (50mg, stabilizes EEG, helps with social), Bumetanide (0.5mg, helps with social), Lexapro (2.5mg, for anxiety)


Hi fatherof2,
Thanks for your detailed post. My son too had birth complications ( vacuum assisted delivery) and I am pretty sure that was the cause for his autism. I am planning to try piracetam. Can you please suggest dosage for it? Did you give it along with choline?. Why have you stopped giving it now ( I mean is it like we should not continue for long periods)?. How long did you give it.?
Thanks

Re: My supplement/drug list for ASD

Posted: Sat Jul 08, 2017 1:20 pm
by FatherOf2
Hanuviji wrote:Hi fatherof2,
Thanks for your detailed post. My son too had birth complications ( vacuum assisted delivery) and I am pretty sure that was the cause for his autism. I am planning to try piracetam. Can you please suggest dosage for it? Did you give it along with choline?. Why have you stopped giving it now ( I mean is it like we should not continue for long periods)?. How long did you give it.?
Thanks

I gave Piracetam at doses 800mg once a day in the morning when my son turned 3 and was nonverbal. We didn't give choline, but it is something recommended for some patients who experience choline depletion from Piracetam and associated headaches. My advise would be to add Antarctic Krill Oil instead of choline because you get a benefit of phosphatidylcholine bonded with EPA and DHA. But at that time I just gave Piracetam, for 9 months. We stopped because the effect plateaued. I gave Piracetam several times after that, but it just gave verbal stims whereas I was looking for more social language. If a child is nonverbal, verbal stims are a blessing. But if a child already talks, they are a distraction. You may try Galantamine in tiny doses (0.5-1mg) at some point. Galantamine resulted in more social language in my son. But Galantamine has only temporary effect on mys son, which disappears after 2-3 weeks, requiring either to increase dose or stop for 1 month and start again. I would also recommend HBOT, but your child has to be seizure-free because HBOT will cause an oxidative stress and possible seizures if a child already has abnormal EEG from pre-existing oxidative stress.

Re: My supplement/drug list for ASD

Posted: Sat Jul 08, 2017 1:30 pm
by FatherOf2
To update: I have been trying Sarcosine on my son for about 1 month at 500mg single dose in the morning (recommended dose is 1000mg 2x/day for adults). This supplement is supposed to support NMDA receptors. So far I haven't noticed anything positive or negative.

We also re-started HBOT this week and noticed higher hyperactivity and return of self-injurious tendencies. HBOT is known to cause initial regression, but I am not sure if I want to see SIBs again. So, I may stop HBOT. The first 2 HBOTs gave visible improvements already in the first week. The 3rd one (last year) was hard to judge. But this 4th one started with regression. Whether it is because of oxidative stress or changing stomach flora remains to be seen. Inulin helped a lot with SIBs reduction. So, there is something in the small intestine that causes SIBs, and HBOT is bringing them back.

Re: My supplement/drug list for ASD

Posted: Sat Jul 08, 2017 6:17 pm
by Hanuviji
FatherOf2 wrote:To update: I have been trying Sarcosine on my son for about 1 month at 500mg single dose in the morning (recommended dose is 1000mg 2x/day for adults). This supplement is supposed to support NMDA receptors. So far I haven't noticed anything positive or negative.

We also re-started HBOT this week and noticed higher hyperactivity and return of self-injurious tendencies. HBOT is known to cause initial regression, but I am not sure if I want to see SIBs again. So, I may stop HBOT. The first 2 HBOTs gave visible improvements already in the first week. The 3rd one (last year) was hard to judge. But this 4th one started with regression. Whether it is because of oxidative stress or changing stomach flora remains to be seen. Inulin helped a lot with SIBs reduction. So, there is something in the small intestine that causes SIBs, and HBOT is bringing them back.

Thank you so much. My son is 3 year old and I am doing biomed for past 6 months. I will definitely look into HBOT .

Re: My supplement/drug list for ASD

Posted: Sun Jul 09, 2017 11:38 pm
by fay
wow, lots on info. :shock:

Re: My supplement/drug list for ASD

Posted: Wed Jul 12, 2017 1:49 am
by miraclev25
Fatherof2


Sports research Krill oil comes with 1000mg, the toddler requirement are 500mg/day,
can we give in alternate day.

would it trigger problem if given everyday 1000mg ?

Re: My supplement/drug list for ASD

Posted: Thu Jul 13, 2017 12:27 pm
by Froy1992
FatherOf2 wrote:I give it in the morning. I give most of my supplements in am except for Taurine anf flaxseed oil, both of which help with sleep.

i'm also doing the exact same thing and it does helps. been said to use in the morning by doctor.. u?

thanks for some treatment plans here tho. gonna try them later!