Creatine transporter deficiency

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Creatineman
Posts: 42
Joined: Tue Jun 13, 2017 7:13 am

Re: Creatine transporter deficiency

Postby Creatineman » Sun Sep 03, 2017 4:05 pm

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Last edited by Creatineman on Wed Nov 08, 2017 8:17 pm, edited 1 time in total.

auract
Posts: 12
Joined: Thu Jun 15, 2017 3:46 pm

Re: Creatine transporter deficiency

Postby auract » Wed Sep 20, 2017 5:33 pm

@Creatineman how did it go with Creatine-Alpha-Ketoglutarate? I'm looking forward to hearing about your experience!

Creatineman
Posts: 42
Joined: Tue Jun 13, 2017 7:13 am

Re: Creatine transporter deficiency

Postby Creatineman » Wed Sep 20, 2017 10:41 pm

auract wrote:@Creatineman how did it go with Creatine-Alpha-Ketoglutarate? I'm looking forward to hearing about your experience!

It did nothing.
Last edited by Creatineman on Wed Nov 08, 2017 8:17 pm, edited 1 time in total.

auract
Posts: 12
Joined: Thu Jun 15, 2017 3:46 pm

Re: Creatine transporter deficiency

Postby auract » Thu Sep 21, 2017 4:11 pm

There is actually as second creatine transporter but it seems to be synthesized only in the retina.
https://www.ncbi.nlm.nih.gov/pubmed/23578822


There are also paralog genes where things get more complicated:
http://www.sciencedirect.com/science/ar ... 191301367X

Regarding the functioning of the transporter, the type of mutation does not easily correlate with the phenotype. For example, even a large deletion does not mean a severe phenotype and small mutations can be lethal to the entire transporter. For example, one base pair mutation may end up encoding an end of gene signal if in the right location. I suspect you're on to something though. It is possible that in some cases that go undetected, a partial transporter may lead to learning impairments that are not severe and definitely no seizures.

Have you seen this paper on fenugreek's effects on how the creatine is assimilated? I've been meaning to try it with monohydrate or glutamate but we're still having difficulties with administering the base formula for supplements
https://link.springer.com/article/10.10 ... 015-1145-1

Creatineman
Posts: 42
Joined: Tue Jun 13, 2017 7:13 am

Re: Creatine transporter deficiency

Postby Creatineman » Thu Sep 21, 2017 9:11 pm

Interesting thanks for those links. There is another creatine transporter in testis also

http://www.sciencedirect.com/science/ar ... 4396902542

There is a mild case of the transport defect here

http://onlinelibrary.wiley.com/doi/10.1 ... 480.x/full

We identified a 3-year-old male with CRTR deficiency referred for study owing to mild psychomotor retardation with independent walking acquired at 18 months and expressive language impairment. He never experienced epileptic seizures. Clinical examination revealed clumsiness in his gait and subtly abnormal hand movements.

After reviewing the clinical description of seven cases under the age of 4 years diagnosed previously,7,10,11,14,15 we conclude that our patient has a mild presentation of this condition with late-onset walking and no seizures or autistic behaviour

Lipoic acid increases creatine uptake also

https://www.ncbi.nlm.nih.gov/pubmed/14669930

I took both ALA, and fenugreek with no effects. Maybe AlA, and fenugreek only work in a normal person with functioning creatine transporters.
Last edited by Creatineman on Thu Oct 05, 2017 6:14 pm, edited 1 time in total.

Creatineman
Posts: 42
Joined: Tue Jun 13, 2017 7:13 am

Re: Creatine transporter deficiency

Postby Creatineman » Wed Sep 27, 2017 6:34 am

Still have not got test results yet.
It is possible to make home made liposomal creatine. The instructions to make liposomal vitamin c are here http://qualityliposomalc.com/ just replace vitamin c with creatine monohydrate.
Last edited by Creatineman on Thu Oct 05, 2017 6:13 pm, edited 1 time in total.

auract
Posts: 12
Joined: Thu Jun 15, 2017 3:46 pm

Re: Creatine transporter deficiency

Postby auract » Mon Oct 02, 2017 4:15 pm

Creatineman, what are your thoughts and have you tried any PCr-Mg-complex? Some papers speculate that this might bypass the CRT1 transporter.

Creatineman
Posts: 42
Joined: Tue Jun 13, 2017 7:13 am

Re: Creatine transporter deficiency

Postby Creatineman » Thu Oct 05, 2017 4:26 am

I tried magnesium creatine chelate for a while which is a chelate like what you mentioned but it didn't do anything.
Last edited by Creatineman on Wed Nov 08, 2017 8:18 pm, edited 2 times in total.

Creatineman
Posts: 42
Joined: Tue Jun 13, 2017 7:13 am

Re: Creatine transporter deficiency

Postby Creatineman » Thu Nov 02, 2017 2:38 am

I just made a batch of pH stable liposomal creatine. Jeff Gollini adds sodium carbonate to creatine monohydrate to get his product Kre alkalyn which is pH 12, and is stable for up to 6 years

https://www.omicsonline.org/open-access ... 000187.pdf

but sodium carbonate even when added in large amounts only got liposomal creatine up to 9-10 pH perhaps because the phosphate groups in the phospholipids in lecithin are acids so resist pH change. Therefore I used a small amount of sodium hydroxide which got the pH up to 11.4 which should make it stable for weeks maybe months. Liposomes are stable for 40 days at room temperate per a patent on them, and someone in the liposomal vitamin c facebook group so making a several week batch of creatine should be fine.

The recipe was
25 g creatine
25g glycerol
60g sunflower lecithin
1.5g sodium hydroxide
over 200ml / g water.

At 50ml twice per day that lasts about 3 days. I am going to get a large jewellery cleaner capable of holding a big glass container so 1l or bigger batch can be made, and then stored in the fridge.

Creatineman
Posts: 42
Joined: Tue Jun 13, 2017 7:13 am

Re: Creatine transporter deficiency

Postby Creatineman » Thu Nov 02, 2017 9:15 am

And creatine amide bonded to leucine like in that patent someone posted above is for sale by VPX- Cremtor

http://www.getrippednutrition.com/VPX_C ... m?CartID=1

Creatineman
Posts: 42
Joined: Tue Jun 13, 2017 7:13 am

Re: Creatine transporter deficiency

Postby Creatineman » Fri Nov 17, 2017 4:29 am

Tried liposomal a bit but didn't seem to work. Maybe because of the high sodium content, and higher pH due to the sodium hydroxide. Will try with calcium hydroxide next week, and lower pH. Also will try tokyo nutritions creatine-decanoate product. The minimum order quantity for pure creatine decanoate from the suppliers is 100kg.


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