Tofisopam, anyone tried this?

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Aspie1983
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Joined: Mon Oct 16, 2017 8:56 am

Tofisopam, anyone tried this?

Postby Aspie1983 » Mon Oct 23, 2017 1:33 pm

Its a Russian drug, thats why it might not be well known in the US and Europe.

https://en.wikipedia.org/wiki/Tofisopam

Tofisopam[1] (Emandaxin, Grandaxin, Sériel) is an anxiolytic that is marketed in several European countries.[2] Chemically, it is a 2,3-benzodiazepine. Unlike other anxiolytic benzodiazepines (which are generally 1,4- or 1,5-substituted) however, tofisopam does not have anticonvulsant, sedative,[3] skeletal muscle relaxant, motor skill-impairing or amnestic[4] properties. While it may not be an anticonvulsant in and of itself, it has been shown to enhance the anticonvulsant action of classical 1,4-benzodiazepines such as diazepam (but not sodium valproate, carbamazepine, phenobarbital, or phenytoin).[5] Tofisopam is indicated for the treatment of anxiety and alcohol withdrawal, and is prescribed in a dosage of 50–300 mg per day divided into three doses. Peak plasma levels are attained two hours after an oral dose. Tofisopam is not reported as causing dependence to the same extent as other benzodiazepines, but is still recommended to be prescribed for a maximum of 12 weeks.
Tofisopam is not approved for sale in the United States or Canada. However, Vela Pharmaceuticals of New Jersey is developing the D-enantiomer (dextofisopam) as a treatment for irritable bowel syndrome,[6] with moderate efficacy demonstrated in clinical trials so far.[7]
Tofisopam is also claimed to be a PDE10A inhibitor, which may provide an alternative mechanism of action for its various therapeutic effects, and this action has been proposed to make tofisopam potentially useful as a treatment for schizophrenia.[8]
Tofisopam has been shown to act as an inhibitor of the liver enzyme CYP3A4,[9] and this could potentially cause dangerous drug interactions with other medications metabolised by this enzyme,[10][11] although the clinical significance of these findings remains unclear.


Rupharma has it aswell as many other websites:

http://rupharma.com/grandaxin/

GRANDAXIN (aka Tofisopam, Emandaxin, Seriel) - is a tranquilizer and belongs to the group of benzodiazepines (atypical benzodiazepine derivative). Has anxiolytic effect and is not accompanied by a sedative, muscle relaxant or anticonvulsant action. It is psychovegetative regulator, which eliminates various forms of autonomic disorders. It has a mild stimulating activity, improves psychomotor and intellectual functions.

USES
Reduce Emotional Stress and Autonomic Disorders
Eliminate Fear and Apathy
Reduce Post Traumatic Stress Disorder
Treat Disorder of Mental Adaptation
Recover from Chronic Alcoholism, Alcohol Withdrawal Syndrome and Delirium
Reduce Depression with Moderately to Severe Psychopathological Symptoms


The cyp3a4 inhibition is the only thing that might put me off a bit, as a lot of drugs use this.

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