Acetaminophen as cause of ASD, ADHD and Asthma

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fiveyearswasted
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Re: Acetaminophen as cause of ASD, ADHD and Asthma

Postby fiveyearswasted » Mon Mar 03, 2014 6:37 pm

mimicry wrote:To be perfectly fair, tylenol use in the Cuba study isn't the only variable factor. Cuba is also closer to the equator that is a correlation in reduced autism rates. Cuba isn't as industrialized, another correlation. Cuba doesn't have the interstate highways...another correlation, the list likely continues.

Tylenol is not a drug to be taken lightly, and I am no where near saying it has zero effect on autism. But this isn't a well designed and controlled study to start accepting it as fact. Just good to once again state that correlation and causation are not the same thing.


Great points. Additionally Cuba has been under economic sanctions for the last 40 years which affects virtually every aspect of the daily lives of the people, and I doubt their version of socialized medicine is directly comparable to ours. Certainly this is not an apples to apples comparison. Still I do believe Dr. Shaw is mostly correct. Regularly subjecting our infants to the coctail of acetaminophen, antibiotics, and toxic poison :P vaccines and heavy metals is doing something, at least to a portion of the population.

I am just glad that Winnie has finally accepted Dr. Shaw as an authoritative figure on the causes of autism. This is wonderful progress! :D

Oh Happy Day!
http://www.youtube.com/watch?v=zxbQrAbeGJc
No scientific evidence that autism has a toxic or allergic basis. - Mr. Barrett

mimicry
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Re: Acetaminophen as cause of ASD, ADHD and Asthma

Postby mimicry » Mon Mar 03, 2014 7:23 pm

Cuba's health system out-performs ours. Families have really good access to primary care. If anything there are less kids falling through the cracks.

http://www.mnn.com/health/fitness-well- ... are-system

fiveyearswasted
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Re: Acetaminophen as cause of ASD, ADHD and Asthma

Postby fiveyearswasted » Mon Mar 03, 2014 8:28 pm

mimicry wrote:Cuba's health system out-performs ours. Families have really good access to primary care. If anything there are less kids falling through the cracks.

http://www.mnn.com/health/fitness-well- ... are-system


Not speaking as a comparison of simply better or worse, that article highlights some of the major differences between our healthcare systems. The point again being that the differences here extend far beyond just how acetaminophen is used with infants and children.

I did a quick search for Cuban vaccine schedules and couldn't find any. I highly doubt it matches the US. I also have to wonder how coverage is in rural areas. Do we have any verification of the validity of Cuban claims to great healthcare? Are they even on the same wavelength as far as diagnosing autism? Or are they diagnosing ASD as MR as some claim we used to do? Cuba just is not a good choice to try to draw direct comparisons from. It is a start though, and a good conversation piece. Something to think about.
No scientific evidence that autism has a toxic or allergic basis. - Mr. Barrett

Winnie
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Re: Acetaminophen as cause of ASD, ADHD and Asthma

Postby Winnie » Mon Mar 03, 2014 8:59 pm

fiveyearswasted wrote: I am just glad that Winnie has finally accepted Dr. Shaw as an authoritative figure on the causes of autism. This is wonderful progress! :D


Shaw is an authority on marketing to the DAN and alt-med industries (Great Plains is probably very profitable), but I wouldn't consider him a player in autism-causation research arena.

The amusing irony here is that his fan base is comprised of the same folks who also accept the more vaccines = more autism notion (and countries that administer more vaccines have more autism = vaccine causation). I doubt the usual anti-vaccine suspects will be trotting this pony out for show.

While it is an interesting hypothesis, I would be surprised if this paper received much attention among legit researchers. The prevalence in Cuba is fundamental to this paper's hypothesis, and this is a problem right out of the gate. I tried to follow the citation for this prevalence, and while I found another slide show where this stat was listed, I didn't find anything else on prevalence or methods -- just another dead end. If one is to believe that fewer than 200 cases exist among 11 million people, some information on the methods used to determine prevalence are essential. Which Shaw should know.

I did find an article about one school in Havana that has fifty-something children with autism. I could not find any info on ID/MR prevalence among school-aged children either.

Without even basic info on prevalence, the paper smacks of just cherry-picking a population where autism is under-identified/reported and Tylenol happens not to be the analgesic of choice.
Winnie
"Make it a powerful memory, the happiest you can remember."

dgdavis64
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Re: Acetaminophen as cause of ASD, ADHD and Asthma

Postby dgdavis64 » Mon Mar 03, 2014 9:02 pm

It seems important to note that this thread was started back in October of last year and then bumped when kulkulkan posted the Norway research etc. There are quite a few links here for someone to be moaning about what I choose to discuss (or not).
In terms of acetaminophen and autism, this is old news imo (I am entitled to have my opinion regardless of the endless bullying) as I discussed it here seven years ago. And as for ironically erroneously assuming what was "read" or not read, clearly the "crashing" of the thread with the reference to the "pediaquacks" was way back on January 12. You'd know that if you weren't so busy dictating and declaring your interpretations of other members you don't even know actions, thoughts and motivations.

My comments and opinions are not an invitation for certain people to swoop in, (leave your nasty waste) as if I'm speaking to you personally. I'm not, go find someone else to harass.

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mimicry
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Re: Acetaminophen as cause of ASD, ADHD and Asthma

Postby mimicry » Mon Mar 03, 2014 9:09 pm

fiveyearswasted wrote:
mimicry wrote:Cuba's health system out-performs ours. Families have really good access to primary care. If anything there are less kids falling through the cracks.

http://www.mnn.com/health/fitness-well- ... are-system


Not speaking as a comparison of simply better or worse, that article highlights some of the major differences between our healthcare systems. The point again being that the differences here extend far beyond just how acetaminophen is used with infants and children.

I did a quick search for Cuban vaccine schedules and couldn't find any. I highly doubt it matches the US. I also have to wonder how coverage is in rural areas. Do we have any verification of the validity of Cuban claims to great healthcare? Are they even on the same wavelength as far as diagnosing autism? Or are they diagnosing ASD as MR as some claim we used to do? Cuba just is not a good choice to try to draw direct comparisons from. It is a start though, and a good conversation piece. Something to think about.

In part of his documentary, Sicko, Michael Moore was there filming in Cuba. The organization that did the maternal health and life expectancy rates is an ngo.

Winnie
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Re: Acetaminophen as cause of ASD, ADHD and Asthma

Postby Winnie » Mon Mar 03, 2014 11:03 pm

dgdavis64 wrote: It seems important to note

Actually doesn't seem important – just you clawing to be right about something again.

dgdavis64 wrote:And as for ironically erroneously assuming what was "read" or not read,

“ironically erroneously” Must add to dgingo.

dg, you posted a swipe, not a point about the paper, and then your swipe revealed that you haven't even read the paper (any of them).

dgdavis64 wrote:My comments and opinions are not an invitation for certain people to swoop in, (leave your nasty waste) as if I'm speaking to you personally.

Oh. :shock: Then which certain person were you speaking to personally and inviting to notice your comment?

dg, Kulkulkan is married.
Winnie
"Make it a powerful memory, the happiest you can remember."

dgdavis64
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Re: Acetaminophen as cause of ASD, ADHD and Asthma

Postby dgdavis64 » Tue Mar 04, 2014 3:01 pm

dgdavis64 wrote:Oh no, it must just be a coincidence (or better diagnosis, lol). Those kids were going to have autism and ADHD anyway, it couldn't be the Tylenol mixed with the toxic poison in all those vaccines.


I don't see anyone's name here, nor do I care who is "married" or not. This is not a "swipe" either, just more of your imagined victim psychosis. It's my opinion which, again I'm free to express where ever I choose despite your continued harassment and bullying.

Beware of the pharma trollbot shills posting from anonymous proxy servers

Winnie
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Re: Acetaminophen as cause of ASD, ADHD and Asthma

Postby Winnie » Tue Mar 04, 2014 3:58 pm

dgdavis64 wrote:
dgdavis64 wrote:Oh no, it must just be a coincidence (or better diagnosis, lol). Those kids were going to have autism and ADHD anyway, it couldn't be the Tylenol mixed with the toxic poison in all those vaccines.


I don't see anyone's name here, nor do I care who is "married" or not. This is not a "swipe" either, just more of your imagined victim psychosis. It's my opinion which, again I'm free to express where ever I choose despite your continued harassment and bullying.


You won't see anything about the cause of autism being "Tylenol mixed with the toxic poison in all those vaccines" in the OP either.

Whose name you are looking for, dg? This is a public discussion forum, not your living room.
Winnie
"Make it a powerful memory, the happiest you can remember."

Jupiter
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Re: Acetaminophen as cause of ASD, ADHD and Asthma

Postby Jupiter » Tue Mar 04, 2014 4:42 pm

Winnie wrote:
Whose name you are looking for, dg? This is a public discussion forum, not your living room.


*cutscene to dg's living room*

dgdavis64
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Re: Acetaminophen as cause of ASD, ADHD and Asthma

Postby dgdavis64 » Tue Mar 04, 2014 5:06 pm

Cute raccoon...Sorry that can't be my living room, Jupiter, Eli's mom, Pirate mom, Krabbypatty, Auntie Em, Soapbox mom, phoenix, give a mouse a cookie, tinkerbell, mint julep, pollyanna, flower child, heffalump etc etc.

At my house, we each have our own bowl of popcorn. But thanks for jumping into the bully pile on bait.

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kulkulkan
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Re: Acetaminophen as cause of ASD, ADHD and Asthma

Postby kulkulkan » Wed Mar 05, 2014 1:59 pm

Looks like Dr Cannell also recently published his views on Tylenol last month. No abstract or full text, but I am guessing that he is highlighting Vitamin D as being protective against oxidative stress (caused by Tylenol or likely many other neurotoxic chemicals). Below is link to his blog.

Paracetamol, oxidative stress, vitamin D and autism spectrum disorders.
Authors Cannell JJ.
Journal Int J Epidemiol. 2014 Feb 11.

http://www.vitamindcouncil.org/blog/dr- ... nd-autism/

A recent review concluded that vitamin D deficiency may be a major risk factor for ASD, in part due to lack of the antioxidant properties of vitamin D. Three recent studies, using community controls, have found that vitamin D levels are significantly lower in children with ASD. Two of the studies (Mostafa et al. and Gong et al.) also found that ASD severity, as rated on standard ASD rating scales, is inversely correlated with vitamin D levels. Mostafa et al. found an R value of. 86 for the association of serum vitamin D with ASD severity on rating scales.

This model (oxidative stress triggering ASD in vitamin D-deficient pregnant women and young children) is one of the theories of ASD with significant support. Other insults that increase oxidative stress are implicated in ASD, such as infections, toxins, fever and inflammation. It may be that acetaminophen exposure is one of several oxidative stressors that trigger ASD development in vitamin D-deficient pregnant women and young children.

I think the evidence is convincing enough to warn people away from using acetaminophen, especially pregnant women and children.

autismepi
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Re: Acetaminophen as cause of ASD, ADHD and Asthma

Postby autismepi » Sat May 10, 2014 11:41 am

One was mentioned already but there are now two large prospective human studies showing associations between prenatal acetaminophen use and adverse neurodevelopment. The first study, by Brandlistuen et al 2013, found that 3 year old children exposed to long term acetaminophen use during pregnancy had substantially adverse developmental outcomes including a 70% increased risk of behavioral and motor problems, as well as, double the risk of communication problems. The second study,by Liew et al. 2014, found that prenatal exposure to acetaminophen increased the risk of ADHD, behavioral problems and hyperkinetic disorders in 7 year olds.

There are numerous studies showing acetaminophen related neurotoxic effects with behavioral abnormalities in animals.
http://www.ncbi.nlm.nih.gov/pubmed/24361869
http://www.ncbi.nlm.nih.gov/pubmed/21170329
http://www.ncbi.nlm.nih.gov/pubmed/22512254
http://www.ncbi.nlm.nih.gov/pubmed/24316461
http://www.ncbi.nlm.nih.gov/pubmed/23850354
http://www.ncbi.nlm.nih.gov/pubmed/21771276
http://www.ncbi.nlm.nih.gov/pubmed/22081409

An interesting note about the extremely high prevalence of autism in S. Korea. The S. Korean Tylenol manufacturing plant was shut down because they were using too high a concentration of acetaminophen. http://www.fiercepharmamanufacturing.co ... 2013-05-16

kulkulkan
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Re: Acetaminophen as cause of ASD, ADHD and Asthma

Postby kulkulkan » Mon Oct 27, 2014 3:16 pm

More correlating evidence of link between ADHD and Acetaminophen use during pregnancy. This one from New Zealand. Full study below.

http://www.plosone.org/article/info%3Ad ... ne.0108210

Associations between Acetaminophen Use during Pregnancy and ADHD Symptoms Measured at Ages 7 and 11 Years
John M. D. Thompson, Karen E. Waldie mail, Clare R. Wall, Rinky Murphy, Edwin A. Mitchell, the ABC study group

Published: September 24, 2014DOI: 10.1371/journal.pone.0108210

Abstract

Objective

Our aim was to replicate and extend the recently found association between acetaminophen use during pregnancy and ADHD symptoms in school-age children.

Methods

Participants were members of the Auckland Birthweight Collaborative Study, a longitudinal study of 871 infants of European descent sampled disproportionately for small for gestational age. Drug use during pregnancy (acetaminophen, aspirin, antacids, and antibiotics) were analysed in relation to behavioural difficulties and ADHD symptoms measured by parent report at age 7 and both parent- and child-report at 11 years of age. The analyses included multiple covariates including birthweight, socioeconomic status and antenatal maternal perceived stress.

Results

Acetaminophen was used by 49.8% of the study mothers during pregnancy. We found significantly higher total difficulty scores (Strengths and Difficulty Questionnaire parent report at age 7 and child report at age 11) if acetaminophen was used during pregnancy, but there were no significant differences associated with any of the other drugs. Children of mothers who used acetaminophen during pregnancy were also at increased risk of ADHD at 7 and 11 years of age (Conners’ Parent Rating Scale-Revised).

Conclusions

These findings strengthen the contention that acetaminophen exposure in pregnancy increases the risk of ADHD-like behaviours. Our study also supports earlier claims that findings are specific to acetaminophen


autismepi
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Re: Acetaminophen as cause of ASD, ADHD and Asthma

Postby autismepi » Sun Feb 15, 2015 9:52 am

A few new research papers and comments to add:

Since the last posts, a new paper by Thompson et al. 2014 has replicated the ADHD findings of Liew et al. 2014 in a New Zealand birth cohort. http://ow.ly/C4NiJ http://bit.ly/1nfKz43. This makes three human population, prospective cohort studies to find an association between prenatal acetaminophen use and adverse neurodevelopmental outcomes. http://bit.ly/1eG2K9u

Here are a few of the animal studies that support this hypothesis: ncbi.nlm.nih.gov/pubmed/24361869 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534986/ http://www.ncbi.nlm.nih.gov/pubmed/24316461 This newest one, shows that when mixed with other endocrine disrupting chemicals, acetaminophen drives the effects on gene expression linked to autism. http://www.ncbi.nlm.nih.gov/pubmed/25607892

Here are two opinion pieces by two groups of researchers suggesting it is time to re-evaluate and remove acetaminophen from use by pregnant women and children. The Duke and U of Colorado researchers are the first US researchers to propose this.
http://www.ncbi.nlm.nih.gov/pubmed/25429980 http://www.ncbi.nlm.nih.gov/pubmed/25634608

And lastly, a plausible explanation for why South Korea's autism prevalence was an outlier in the country level correlation study (Bauer and Kriebel 2013). The Tylenol plant in South Korea has shutdown for been putting excessive acetaminophen in the bottles.
http://www.fiercepharmamanufacturing.co ... 2013-05-16

dgdavis64
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Re: Acetaminophen as cause of ASD, ADHD and Asthma

Postby dgdavis64 » Fri Mar 13, 2015 10:48 am

This may have even more to do with it... I wonder how long this has really been going on?



Tylenol maker to pay $25 million for selling metal-contaminated drugs


By Lindsay Dunsmuir

WASHINGTON Tue Mar 10, 2015 4:37pm EDT

(Reuters) - A Johnson & Johnson subsidiary pleaded guilty on Tuesday to selling liquid medicine contaminated with metal and agreed to pay $25 million to resolve the case, the U.S. Department of Justice said on Tuesday.

The subsidiary, McNeil Consumer Healthcare, pleaded guilty to one federal criminal charge in the case.

In 2010, the company launched mass recalls of certain children's over-the-counter-medicines, including Infants' Tylenol and Children's Motrin, made at its Fort Washington, Pennsylvania plant.

http://www.reuters.com/article/2015/03/ ... 9S20150310

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kulkulkan
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Re: Acetaminophen as cause of ASD, ADHD and Asthma

Postby kulkulkan » Fri Mar 13, 2015 12:14 pm

Here is one pediatric death likely attributable to Tylenol. Whether defective or not, it can cause death with over a thousand cases reported now (so do other NSAIDs) and according to one article, reason for 78,000 ER visits and number one cause of acute liver failure in the US.

http://globalnews.ca/news/196324/couple ... es-that-2/

This is one drug that should be removed as OTC if not banned altogether for pregnant women and children.


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