Single Dose Reverses Autism-like Symptoms in Mice
Old drug used for sleeping sickness may point to new treatment in humans
In a further test of a novel theory that suggests autism is the consequence of abnormal cell communication, researchers at the University of California, San Diego School of Medicine report that an almost century-old drug approved for treating sleeping sickness also restores normal cellular signaling in a mouse model of autism, reversing symptoms of the neurological disorder in animals that were the human biological age equivalent of 30 years old.
The findings, published in the June 17, 2014 online issue of Translational Psychiatry, follow up on similar research published last year by senior author Robert K. Naviaux, MD, PhD, professor of medicine, pediatrics and pathology, and colleagues.
Naviaux said the findings fit neatly with the idea that autism is caused by a multitude of interconnected factors: “Twenty percent of the known factors associated with autism are genetic, but most are not. It’s wrong to think of genes and the environment as separate and independent factors. Genes and environmental factors interact. The net result of this interaction is metabolism.”
Rest of the article here http://ucsdnews.ucsd.edu/pressrelease/s ... ms_in_mice
Full study here: http://www.nature.com/tp/journal/v4/n6/ ... 1433a.html
A table of 18 biochemical pathways that were studied:
http://www.nature.com/tp/journal/v4/n6/ ... gure-title