Serum Zn/Cu levels in ASD

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Serum Zn/Cu levels in ASD

Postby kulkulkan » Tue Sep 16, 2014 10:26 am

Low Zn/Cu is not new finding in ASD context, but what is interesting in this study is negative correlation with CARS as well the high sensitivity and specificity for ASD (90%+) using ratio of 0.665 (for the group studied n=60). We did do the Zn/Cu blood test a couple of times but don't recall the ratio.

Neuroreport. 2014 Oct 22;25(15):1216-20. doi: 10.1097/WNR.0000000000000251.
Serum copper and zinc levels in individuals with autism spectrum disorders.
Li SO1, Wang JL, Bjørklund G, Zhao WN, Yin CH.
Author information
Trace elements play a critical role in the pathogenesis of autism spectrum disorders (ASD). The aim of this study was to investigate the serum levels of zinc (Zn) and copper (Cu) in Chinese children with ASD. Sixty patients (48 males, 12 females) diagnosed with ASD and 60 healthy sex-matched and age-matched control participants were assessed for serum Zn and Cu content at admission. The severity of ASD was also evaluated using the Childhood Autism Rating Scale (CARS) score. The results indicated that the mean serum Zn levels and Zn/Cu ratio were significantly lower in children with ASD compared with normal cases (P<0.001, respectively), whereas serum Cu levels were significantly higher (P<0.001). There was a significant negative association between Zn/Cu and CARS scores (r=-0.345, P=0.007). On the basis of the receiver operating characteristic curve, the optimal cut-off value of serum levels of Zn/Cu as an indicator for an auxiliary diagnosis of autism was projected to be 0.665, which yielded a sensitivity of 90.0% and a specificity of 91.7%; the area under the curve was 0.968 (95% confidence interval, 0.943-0.993). In conclusion, these results suggested an association between serum levels of Zn and Cu and ASD among Chinese patients, and the Zn/Cu ratio could be considered a biomarker of ASD.

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