Is atopy in early childhood a risk factor for ADHD and ASD?

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María Luján
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Joined: Sun Jun 25, 2006 5:26 pm

Is atopy in early childhood a risk factor for ADHD and ASD?

Postby María Luján » Sun Nov 09, 2014 9:05 am

Is atopy in early childhood a risk factor for ADHD and ASD? A longitudinal study.
OBJECTIVE:
Previous studies have found a temporal concordance in the increased prevalence of atopic diathesis/atopic diseases, attention-deficit hyperactivity disorder (ADHD), and autistic spectrum disorder (ASD) worldwide. But, the temporal association among these 3 distinct diseases is unknown.
METHOD:
14,812 atopic subjects diagnosed with any atopic disease (asthma, atopic dermatitis, allergic rhinitis, or allergic conjunctivitis) before the age of 3 (atopic cohort) and 6944 non-atopic subjects with no lifetime atopic disease (non-atopic cohort), born between 1997 and 2000, were enrolled and followed to December 31, 2010 to identify the development of ADHD and ASD.
RESULTS:
The presence of any atopic disease in early childhood increased the risk of developing ADHD (hazard ratio [HR]: 1.97) and ASD (HR: 3.40) in later life. Greater numbers of atopic comorbidities (4 comorbidities: ADHD: HR: 2.53; ASD: HR: 4.29) were significantly related to a greater risk of developing ADHD and ASD.
DISCUSSION:
Atopic diathesis in early childhood elevated the risk of developing ADHD and ASD in later life, with the dose-dependent relationship of more atopic comorbidities with a greater likelihood of ADHD and ASD.

http://www.ncbi.nlm.nih.gov/pubmed/25280829

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