H1N1 association with narcolepsy and ADHD

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kulkulkan
Posts: 2075
Joined: Tue Mar 13, 2012 1:37 pm

H1N1 association with narcolepsy and ADHD

Postby kulkulkan » Tue Nov 11, 2014 3:51 pm

I believe this is most significant factor for us and predict that the 2009/2010 birth cohort (H1N1 cohort) will have the highest prevalence for neurodisorders, not just ASD. Just need to wait another decade for that data.

http://questioning-answers.blogspot.ca/ ... lepsy.html

http://www.ncbi.nlm.nih.gov/pubmed/25325473

Sleep. 2014 Oct 17. pii: sp-00241-14. [Epub ahead of print]
Psychiatric Comorbidity and Cognitive Profile in Children With Narcolepsy With or Without Association to the H1N1 Influenza Vaccination.
Szakács A, Hallböök T, Tideman P, Darin N, Wentz E.
Author information
Abstract

OBJECTIVES:
To evaluate psychiatric comorbidity and the cognitive profile in children and adolescents with narcolepsy in western Sweden and the relationship of these problems to H1N1 vaccination.

PATIENTS:
Thirty-eight patients were included in the study.

DESIGN:
We performed a population-based, cross-sectional study to investigate psychiatric comorbidity using a test battery of semistructured interviews generating Diagnostic and Statistical Manual of Mental Disorders, 4th Edition diagnoses, including the Development and Well-Being Assessment and the attention deficit hyperactivity disorder rating scale. The Autism Spectrum Screening Questionnaire and the Positive and Negative Syndrome Scale were used to screen for autistic traits and psychotic symptoms, respectively. The cognitive assessments were made by a clinical psychologist using the Wechsler Preschool and Primary Scale of Intelligence, Third Edition, the Wechsler Intelligence Scale for Children, Fourth Edition, or the Wechsler Adult Intelligence Scale, Fourth Edition.

MEASUREMENTS AND RESULTS:
In the post-H1N1 vaccination (PHV) narcolepsy group (n = 31), 43% of patients had psychiatric comorbidity, 29% had attention deficit hyperactivity disorder (ADHD) inattentive type, 20% had major depression, 10% had general anxiety disorder, 7% had oppositional defiant disorder (ODD), 3% had pervasive developmental disorder not otherwise specified (i.e., atypical autism), and 3% had eating disorder not otherwise specified (anorectic type). In the non-post-H1N1 vaccination (nPHV) narcolepsy group, one of seven patients had ADHD, inattentive type and ODD. The most frequent psychiatric symptom was temper tantrums, which occurred in 94% of the patients in the PHV group and 71% of the patients in the nPHV narcolepsy group. The cognitive assessment profile was similar in both groups and showed normal results for mean full-scale IQ and perceptual speed but decreased verbal comprehension and working memory. Patients with psychiatric comorbidity had a significantly lower full-scale IQ compared to those without.

CONCLUSION:
Our study indicates increased psychiatric comorbidity in children and adolescents with narcolepsy. The identified cognitive profile with significantly lower verbal comprehension and working memory compared with the normal mean index could have important implications for social relations and schooling. The small numbers of patients with nPHV narcolepsy make it difficult to draw firm conclusions about the possible differences between the two groups of patients.
© 2014 Associated Professional Sleep Societies, LLC.

noelm
Posts: 404
Joined: Tue Jun 21, 2011 2:50 pm

Re: H1N1 association with narcolepsy and ADHD

Postby noelm » Sun Nov 30, 2014 8:23 am

I wouldn't restrict to 2009/2010 birth cohort only. DS is born in 2008 and has gotten H1N1 vaccine before age of 1 (Dx at 20 months). I came across some info that H1N1 vaccine shots marketed in the EU were different than those in the US. DS has gotten the shot from the EU stock, in which narcolepsy was observed. Correct me if this was observed in the US stock as well.
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