GABA/Glutamate imbalance and neuroinflammation in ASD

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kulkulkan
Posts: 2075
Joined: Tue Mar 13, 2012 1:37 pm

GABA/Glutamate imbalance and neuroinflammation in ASD

Postby kulkulkan » Mon Nov 24, 2014 5:41 pm

Interesting GABA was elevated in ASD as well.

Full text here. http://www.jneuroinflammation.com/conte ... 0189-0.pdf

GABAergic/glutamatergic imbalance relative to excessive neuroinflammation in autism spectrum disorders.

Authors
El-Ansary A, Al-Ayadhi L.
Journal
J Neuroinflammation. 2014 Nov 19;11(1):189. [Epub ahead of print]

Affiliation
Abstract
Background
Autism spectrum disorder (ASD) is characterized by three core behavioral domains: social deficits, impaired communication, and repetitive behaviors. Glutamatergic/GABAergic imbalance has been found in various preclinical models of ASD. Additionally, autoimmunity immune dysfunction, and neuroinflammation are also considered as etiological mechanisms of this disorder. This study aimed to elucidate the relationship between glutamatergic/ GABAergic imbalance and neuroinflammation as two recently-discovered autism-related etiological mechanisms.

Methods
Twenty autistic patients aged 3 to 15 years and 19 age- and gender-matched healthy controls were included in this study. The plasma levels of glutamate, GABA and glutamate/GABA ratio as markers of excitotoxicity together with TNF-¿, IL-6, IFN-¿ and IFI16 as markers of neuroinflammation were determined in both groups.

Results
Autistic patients exhibited glutamate excitotoxicity based on a much higher glutamate concentration in the autistic patients than in the control subjects. Unexpectedly higher GABA and lower glutamate/GABA levels were recorded in autistic patients compared to control subjects. TNF-¿ and IL-6 were significantly lower, whereas IFN-¿ and IFI16 were remarkably higher in the autistic patients than in the control subjects.

Conclusion
Multiple regression analysis revealed associations between reduced GABA level, neuroinflammation and glutamate excitotoxicity. This study indicates that autism is a developmental synaptic disorder showing imbalance in GABAergic and glutamatergic synapses as a consequence of neuroinflammation.

noelm
Posts: 404
Joined: Tue Jun 21, 2011 2:50 pm

Re: GABA/Glutamate imbalance and neuroinflammation in ASD

Postby noelm » Sun Nov 30, 2014 8:02 am

Little offnote,

Can anyone clear my confusion? I always thought that GABA molecule is too big to cross blood brain barrier and if any child benefits from use of GABA supplement then the blood brain barrier is leaky (and hence possibly more brain inflammation). If GABA does not help the child then BBB is not leaky.

If the paper conclusion stand across the board, then its little puzzling that many parents supplement it even more and notice benefit.
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