Thioredoxin: a novel marker of oxidative stress in ASD

Discuss autism theories, media stories, and efforts to put ASD on the government agenda here.

Moderator: ModeratorBill

Forum rules
Please limit quotes from articles to five paragraphs. Also, researchers may post study information here.
kulkulkan
Posts: 2075
Joined: Tue Mar 13, 2012 1:37 pm

Thioredoxin: a novel marker of oxidative stress in ASD

Postby kulkulkan » Mon Dec 01, 2014 5:53 pm

Hadn't seen this novel marker of oxidative stress before in ASD context. Also correlated to severity.

http://www.ncbi.nlm.nih.gov/pubmed/25433158

Int J Dev Neurosci. 2014 Nov 26. pii: S0736-5748(14)00191-9. doi: 10.1016/j.ijdevneu.2014.11.007. [Epub ahead of print]
Thioredoxin: A novel, independent diagnosis marker in children with autism.
Zhang QB1, Gao SJ1, Zhao HX2.
Author information

Abstract

BACKGROUND:
Oxidative stress increases serum thioredoxin (TRX), a redox-regulating protein with antioxidant activity recognized as an oxidative-stress marker. The aim of this study was to assess the clinical significance of serum TRX levels in Autism spectrum disorders (ASD).

METHODS:
Eighty patients diagnosed with ASD and 100 sex and age matched typically developing children were assessed for serum TRX content at admission. TRX were assayed with solid-phase sandwich ELISA, and severity of ASD was evaluated with the Childhood Autism Rating Scale (CARS) Score.

RESULTS:
The results indicated that the median serum TRX levels were significantly (P<0.0001) higher in children with ASD as compared to typically developing children [17.9(IQR: 10.7-25.8 ) ng/ml and 5.5(3.6-9.2) ng/ml, respectively]. Levels of TRX increased with increasing severity of ASD as defined by the CARS score. After adjusting for all other possible covariates, TRX still was an independent diagnosis marker of ASD with an adjusted OR of 1.454 (95% CI, 1.232-1.892; P<0.0001). Based on the receiver operating characteristic (ROC) curve, the optimal cut-off value of serum TRX levels as an indicator for auxiliary diagnosis of autism was projected to be 10.6ng/ml. Further, we found that an increased diagnosis of ASD was associated with TRX levels ≥10.6ng/ml (adjusted OR 15.31, 95% CI: 7.36-31.85) after adjusting for possible confounders.

CONCLUSIONS:
Our study demonstrated that serum TRX levels were associated with ASD, and elevated levels could be considered as a novel, independent diagnosis indicator of ASD.

Copyright © 2014. Published by Elsevier Ltd.

KEYWORDS:
Autism spectrum disorders; Chinese; Oxidative-stress; Thioredoxin
PMID: 25433158 [PubMed - as supplied by publisher]


kulkulkan
Posts: 2075
Joined: Tue Mar 13, 2012 1:37 pm

Re: Thioredoxin: a novel marker of oxidative stress in ASD

Postby kulkulkan » Mon Dec 01, 2014 7:11 pm

Looks like this marker had been published before in ASD context by the Saudi research group. Also found elevated. Full text available.

http://link.springer.com/article/10.118 ... 377-11-139


Return to “Autism Articles, Studies & Politics”