Role of trace elements, thiamin and transkelotase in ASD

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kulkulkan
Posts: 2075
Joined: Tue Mar 13, 2012 1:37 pm

Role of trace elements, thiamin and transkelotase in ASD

Postby kulkulkan » Mon Jan 05, 2015 7:20 pm

Hypothesis.

http://www.ncbi.nlm.nih.gov/pubmed/25553376/
The role of trace elements, thiamin (e) and transketolase in autism and autistic spectrum disorder.

Authors
Obrenovich ME1, Shola D1, Schroedel K1, Agrahari A1, Lonsdale D1.
Author information
Journal
Front Biosci (Elite Ed). 2015 Jan 1;7:263-77.

Affiliation
Abstract
Although there has been much research into autism or autistic spectrum disorder (ASD), there is room for considerable conjecture regarding the etiology of these developmental brain disorders. ASD is marked by a complex interaction between environmental factors and genetic predisposition, including epistasis. This manuscript argues that changes in oxidative metabolism, thiamine homeostasis, heavy metal deposition and cellular immunity have a role in the etiopathogenesis of autism and ASD. Recent findings from our group and others provide evidence for abnormal thiol metabolism, marked by significant alteration in the deposition of several trace heavy metal species. Together with these, we find differences in thiamine homeostasis in ASD patients, which can be corrected by supplementation. We hypothesize that altered thiol metabolism from heavy metal toxicity, one of the key mechanisms for oxidative stress production, may be responsible for the biochemical alterations in transketolase, dysautonomia and abnormal thiamine homeostasis. Although it is unknown why these particular metals accumulate, we suspect that children with ASD and forms of autism may have particular trouble excreting thiol-toxic heavy metal species, many of which exist as divalent cations. We maintain mercury accumulation is evidence of altered clearance. Together with concomitant oxidative stress, these findings may offer an intriguing component or possible mechanism for oxidative stress-mediated neurodegeneration in ASD patients. Regardless of the exact cause, these factors may be more important to the etiology of this symptomatically diverse disease spectrum. Here, we offer insight into new avenues of exploration as well as the development of novel treatment approaches for these growing and devastating diseases.


dgdavis64
Posts: 5241
Joined: Sun Mar 20, 2005 11:51 pm

Re: Role of trace elements, thiamin and transkelotase in ASD

Postby dgdavis64 » Tue Jan 06, 2015 11:16 pm

"Although it is unknown why these particular metals accumulate, we suspect that children with ASD and forms of autism may have particular trouble excreting thiol-toxic heavy metal species, many of which exist as divalent cations. We maintain mercury accumulation is evidence of altered clearance."


Many parents here were saying this back in 2005. Good to see the science finally catching up! Thanks for sharing this.

Beware of the pharma trollbot shills posting from anonymous proxy servers

kulkulkan
Posts: 2075
Joined: Tue Mar 13, 2012 1:37 pm

Re: Role of trace elements, thiamin and transkelotase in ASD

Postby kulkulkan » Wed Jan 07, 2015 11:10 am

The hypothesis is an older one (first published in 2011) - likely hasn't changed much, just updated with newer studies. Don't have full text but would like to know the specifics. And Lonsdale who is one of the main authors was the first and only one to ever try TTFD as a rather weak chelator / thiamine source in 2002 in a small uncontrolled ASD trial that did show efficacy. So I wouldn't say science has necessarily caught up but rather been ignored for long time.


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