Evaluation of Intestinal Function in Children with Autism and Gastrointestinal Symptoms.

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Winnie
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Evaluation of Intestinal Function in Children with Autism and Gastrointestinal Symptoms.

Postby Winnie » Tue Mar 15, 2016 1:05 pm

J Pediatr Gastroenterol Nutr. 2016 Feb 20. [Epub ahead of print]

Evaluation of Intestinal Function in Children with Autism and Gastrointestinal Symptoms.

Kushak RI1, Buie TM, Murray KF, Newburg DS, Chen C, Nestoridi E, Winter HS.

Abstract

OBJECTIVE:

Alterations in intestinal function, often characterized as a "leaky gut", have been attributed to children who are on the autism spectrum. Disaccharidase activity, intestinal inflammation and permeability were analyzed in 61 children with autism and 50 non-autistic individuals with gastrointestinal symptoms.

METHODS:

All patients had duodenal biopsies assayed for lactase, sucrase, maltase and palatinase activity. Intestinal permeability was evaluated by rhamnose/lactulose test and measured by HPLC-MS. Intestinal inflammation was evaluated by fecal calprotectin and lactoferrin levels using ELISA as well as histology.

RESULTS:

Some autistic children had mild levels of mucosal inflammation on intestinal biopsy. Disaccharidase activity was not different in autistic and non-autistic individuals. Fecal calprotectin and lactoferrin were similar in both groups. Differences between lactulose and rhamnose recovery and lactulose/rhamnose ratio in urine were not statistically different in patients with and without autism.

CONCLUSION:

This study supports the observation that children with autism who have symptoms of gastrointestinal disorders have objective findings similar to children without autism. Neither non-invasive testing nor endoscopic findings identify gastrointestinal pathology specific to autism, but may be of benefit in identifying children with autism who have atypical symptoms.

http://www.ncbi.nlm.nih.gov/pubmed/26913756
Winnie
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