Evaluation of Intestinal Function in Children With Autism and Gastrointestinal Symptoms

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Winnie
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Joined: Sat Mar 18, 2006 2:48 pm

Evaluation of Intestinal Function in Children With Autism and Gastrointestinal Symptoms

Postby Winnie » Mon Sep 05, 2016 1:07 am

J Pediatr Gastroenterol Nutr. 2016 May;62(5):687-91. doi: 10.1097/MPG.0000000000001174.

Evaluation of Intestinal Function in Children With Autism and Gastrointestinal Symptoms.

Kushak RI1, Buie TM, Murray KF, Newburg DS, Chen C, Nestoridi E, Winter HS.

Abstract

OBJECTIVE:

Alterations in intestinal function, often characterized as a "leaky gut," have been attributed to children who are on the autism spectrum. Disaccharidase activity, intestinal inflammation, and permeability were analyzed in 61 children with autism and 50 nonautistic individuals with gastrointestinal symptoms.

METHODS:

All patients had duodenal biopsies assayed for lactase, sucrase, maltase, and palatinase activity. Intestinal permeability was evaluated by rhamnose/lactulose test and measured by high-performance liquid chromatography-mass spectrometry. Intestinal inflammation was evaluated by fecal calprotectin and lactoferrin levels using enzyme-linked immunosorbent assay and histology.

RESULTS:

Some children with autism had mild levels of mucosal inflammation on intestinal biopsy. Disaccharidase activity was not different in autistic and nonautistic individuals. Fecal calprotectin and lactoferrin were similar in both groups. Differences between lactulose and rhamnose recovery and lactulose/rhamnose ratio in urine were not statistically different in patients with and without autism.

CONCLUSIONS:

The present study supports the observation that children with autism who have symptoms of gastrointestinal disorders have objective findings similar to children without autism. Neither noninvasive testing nor endoscopic findings identify gastrointestinal pathology specific to autism, but may be of benefit in identifying children with autism who have atypical symptoms.

http://www.ncbi.nlm.nih.gov/pubmed/26913756
Winnie
"Make it a powerful memory, the happiest you can remember."

jaumeb
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Joined: Fri Mar 25, 2016 10:48 am

Re: Evaluation of Intestinal Function in Children With Autism and Gastrointestinal Symptoms

Postby jaumeb » Mon Sep 05, 2016 6:59 am

Thanks for the study. I think that digestive symptoms (diarrhea, constipation, bloating, flatulence, abdominal pain, etc.) are much more likely to occur among autistic patients than in the general population. And is my belief that autism is, in fact, a digestive problem.

I wish that the researchers find some day either biomarkers or some other means to measure the digestive problems associated with autism.

I think dr Krigsman is the one making progress in the right direction.

Winnie
Posts: 4227
Joined: Sat Mar 18, 2006 2:48 pm

Re: Evaluation of Intestinal Function in Children With Autism and Gastrointestinal Symptoms

Postby Winnie » Wed Sep 07, 2016 2:59 am

jaumeb wrote:I wish that the researchers find some day either biomarkers or some other means to measure the digestive problems associated with autism.

The study essentially found that there was no pathology specific to autism. The findings among children with autism who have GI problems were similar to the GI problems in children without autism.

jaumeb wrote:I think dr Krigsman is the one making progress in the right direction.

I don't agree -- Krigsman is more about scopes and $$ than research.

Tim Buie and others have and are conducting far more research.
Winnie
"Make it a powerful memory, the happiest you can remember."


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