Hair toxic and essential trace elements in children with autism spectrum disorder.

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Winnie
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Joined: Sat Mar 18, 2006 2:48 pm

Hair toxic and essential trace elements in children with autism spectrum disorder.

Postby Winnie » Mon Sep 05, 2016 1:09 am

Metab Brain Dis. 2016 Aug 31. [Epub ahead of print]

Hair toxic and essential trace elements in children with autism spectrum disorder.

Skalny AV1,2,3,4, Simashkova NV5, Klyushnik TP5, Grabeklis AR6, Bjørklund G7, Skalnaya MG8,9, Nikonorov AA10,11, Tinkov AA10,6,8,11.

Abstract

The objective of the study was to investigate hair trace elements content in children suffering from autism spectrum disorder (ASD). A total of 74 ASD children and 74 sex- and age-matched controls divided into two age groups (2-4 and 5-9 years) were investigated. Hair trace elements content was assessed using inductively coupled plasma mass spectrometry. A general cohort of ASD children was characterized by 29 %, 41 %, and 24 % lower hair levels of chromium (Cr), iodine (I), and vanadium (V), respectively, whereas the level of selenium (Se) exceeded the respective control values by 31 %. In ASD children aged 2-4 years hair Cr, I and V content was 68 %, 36 % and 41 % lower than in the controls. Older ASD children were characterized by 45 % increase in hair Se levels. In a general cohort of ASD children hair beryllium (Be) and tin (Sn) levels were 50 % and 34 % lower than the control values. In the first age group (2-4 years) of ASD children 34 %, 42 %, and 73 % lower levels of arsenic (As), boron (B), and Be were detected. In the second age group of ASD children only a nearly significant 25 % decrease in hair lead (Pb) was detected. Surprisingly, no significant group difference in hair mercury (Hg), zinc (Zn), and copper (Cu) content was detected. Generally, the results of the present study demonstrate that children with ASD are characterized by lower values in hair of not only essential but also toxic trace elements.

http://www.ncbi.nlm.nih.gov/pubmed/27581303
Winnie
"Make it a powerful memory, the happiest you can remember."

jaumeb
Posts: 167
Joined: Fri Mar 25, 2016 10:48 am

Re: Hair toxic and essential trace elements in children with autism spectrum disorder.

Postby jaumeb » Mon Sep 05, 2016 6:32 am

Thanks for sharing this. Some say that autist patients have malfunctioning detox mechanism. These results seem to support that idea.

Winnie
Posts: 4227
Joined: Sat Mar 18, 2006 2:48 pm

Re: Hair toxic and essential trace elements in children with autism spectrum disorder.

Postby Winnie » Wed Sep 07, 2016 3:09 am

Since the presence of mercury in hair is due to passive diffusion and/or absorption, the results would not be due to a malfunctioning detox system.
Winnie
"Make it a powerful memory, the happiest you can remember."

AspieGenes
Posts: 114
Joined: Wed Sep 28, 2016 12:32 pm

Re: Hair toxic and essential trace elements in children with autism spectrum disorder.

Postby AspieGenes » Thu Sep 29, 2016 9:16 am

Winnie wrote:Since the presence of mercury in hair is due to passive diffusion and/or absorption, the results would not be due to a malfunctioning detox system.


Are you sure about this? I thought Mercury had to bind with sulfate and/or Metallothioneine. But I am almost certain it is not passive.

https://en.wikipedia.org/wiki/Metallothionein

http://ehp.niehs.nih.gov/1104079/

http://www.sciencedirect.com/science/ar ... 5115301602

And this study shows how genetics can alter the amount of mercury in the hair: ABCC1 is a transporter.

http://www.sciencedirect.com/science/ar ... 2016302112


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