Omega 3/6 fatty acids for reading in children: a randomized, double-blind, placebo-controlled trial in 9-year-olds

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Winnie
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Joined: Sat Mar 18, 2006 2:48 pm

Omega 3/6 fatty acids for reading in children: a randomized, double-blind, placebo-controlled trial in 9-year-olds

Postby Winnie » Wed Sep 07, 2016 4:20 pm

(sorry, had to shorten title to fit in subject line)

J Child Psychol Psychiatry. 2016 Aug 22. doi: 10.1111/jcpp.12614. [Epub ahead of print]

Omega 3/6 fatty acids for reading in children: a randomized, double-blind, placebo-controlled trial in 9-year-old mainstream schoolchildren in Sweden.

Johnson M1, Fransson G1, Östlund S1, Areskoug B1, Gillberg C1.

BACKGROUND:

Previous research has shown positive effects of Omega 3/6 fatty acids in children with inattention and reading difficulties. We aimed to investigate if Omega 3/6 improved reading ability in mainstream schoolchildren.

METHODS:

We performed a 3-month parallel, randomized, double-blind, placebo-controlled trial followed by 3-month active treatment for all subjects. Mainstream schoolchildren aged 9-10 years were randomized 1:1 to receive three Omega 3/6 capsules twice daily or identical placebo. Assessments were made at baseline, 3 months, and 6 months. The primary outcome measure was the Logos test battery for evaluating reading abilities. The trial is registered with ClinicalTrials.gov, number NCT02557477.

RESULTS:

The study enrolled 154 children (active n = 78; placebo n = 76), of whom 122 completed the first 3 months (active n = 64; placebo n = 58) and 105 completed the whole study (active/active n = 55; placebo/active n = 50). Outcomes were assessed by per protocol (PP) and intention-to-treat (ITT) analyses. Active treatment was superior to placebo at 3 months for improvement in phonologic decoding time (PP active/placebo difference -0.16; 95% CI -0.03, -0.29; effect size (ES) .44; p = .005; and ITT ES .37; p = .036), in visual analysis time (PP active/placebo difference -0.19; 95% CI -0.05, -0.33; ES .49; p = .013; and ITT ES .40; p = .01), and for boys in phonologic decoding time (PP -0.22; 95% CI -0.03, -0.41; ES .62; p = .004). Children with ADHD-RS scores above the median showed treatment benefits in visual analysis time (PP ES .8, p = .009), reading speed per word (PP ES .61, p = .008), and phonologic decoding time per word (PP ES .85, p = .006). Adverse events were rare and mild, mainly stomach pain/diarrhea (active n = 9, placebo n = 2).

CONCLUSIONS:

Compared with placebo, 3 months of Omega 3/6 treatment improved reading ability - specifically the clinically relevant 'phonologic decoding time' and 'visual analysis time' - in mainstream schoolchildren. In particular, children with attention problems showed treatment benefits.

http://www.ncbi.nlm.nih.gov/pubmed/27545509
Winnie
"Make it a powerful memory, the happiest you can remember."

jaumeb
Posts: 167
Joined: Fri Mar 25, 2016 10:48 am

Re: Omega 3/6 fatty acids for reading in children: a randomized, double-blind, placebo-controlled trial in 9-year-olds

Postby jaumeb » Thu Sep 08, 2016 6:14 am

My idea was that omega3 was the one is needed as we normally get enough omega6 for diet. Interesting stuff.


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