(Autism Link Inside) Alcohol shown to act in same way as rapid antidepressants

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AspieGenes
Posts: 114
Joined: Wed Sep 28, 2016 12:32 pm

(Autism Link Inside) Alcohol shown to act in same way as rapid antidepressants

Postby AspieGenes » Thu Sep 29, 2016 1:00 pm

So this is fascinating. Alcohol blocks a specific glutamate receptor which changes GABA from a sedative to a stimulant.

https://www.sciencedaily.com/releases/2 ... 153538.htm

In their study using an animal model, Raab-Graham and her colleagues found that a single dose of an intoxicating level of alcohol, which has been shown to block NMDA (Glutamate) receptors (proteins associated with learning and memory), worked in conjunction with the autism-related protein FMRP to transform an acid called GABA from an inhibitor to a stimulator of neural activity. In addition, the research team found that these biochemical changes resulted in non-depressive behavior lasting at least 24 hours.


The FMRP protein they are talking about is made by a gene called FMR1 that plays a big role in synaptic plasticity.
http://www.uniprot.org/uniprot/Q06787

jaumeb
Posts: 167
Joined: Fri Mar 25, 2016 10:48 am

Re: (Autism Link Inside) Alcohol shown to act in same way as rapid antidepressants

Postby jaumeb » Fri Sep 30, 2016 10:12 am

What are the implications? Are autists always drunk?

AspieGenes
Posts: 114
Joined: Wed Sep 28, 2016 12:32 pm

Re: (Autism Link Inside) Alcohol shown to act in same way as rapid antidepressants

Postby AspieGenes » Fri Sep 30, 2016 10:14 pm

jaumeb wrote:What are the implications? Are autists always drunk?


Ha, I don't know how you got that out of the study.

It says that alchohol blocks a glutamate receptor (glutamate is always high in Autsitics) and when it does that it changes the function of GABA from inhibition to excitatory using a gene IMPLICATED IN AUTISM. Glutamate excitement is bad for ASD, GABA excitement is good for ASD.

This means that maybe NMDA blockers would help ASD symptoms. As well as lowering glutamate levels if you can find out why they are high.

jaumeb
Posts: 167
Joined: Fri Mar 25, 2016 10:48 am

Re: (Autism Link Inside) Alcohol shown to act in same way as rapid antidepressants

Postby jaumeb » Sat Oct 01, 2016 6:54 am

Thanks for the clarification. I really needed it.


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