Mitochondrial dysfunction in autism spectrum disorders

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AspieGenes
Posts: 114
Joined: Wed Sep 28, 2016 12:32 pm

Mitochondrial dysfunction in autism spectrum disorders

Postby AspieGenes » Sat Oct 29, 2016 1:56 pm

New study, goes along with my theory on Sulfite Oxidase, a mitochondrial enzyme, being at the center of ASD.

Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis
http://sci-hub.cc/10.1038/mp.2010.136

Secondary mitochondrial dysfunction in ASD
A majority (79%) of the children with ASD/MD
identified in this review did not possess a genetic
etiology that might account for mitochondrial dysfunction.
Although a yet unidentified genetic defect
may be present in some of these cases, secondary
mitochondrial dysfunction is likely.9,85 Biochemical
abnormalities reported in some children with
ASD could contribute to secondary mitochondrial
dysfunction. For example, several studies have
documented a significantly lower mean GSH concentration110,130,185–189
and a lower mitochondrial GSH
reserve35 in children with ASD as compared with
controls. GSH depletion is associated with impaired
mitochondrial function73 and increased ROS production.36
Increased ROS can impair mitochondrial
function36,190 and may be particularly significant in
individuals with ASD because they have been shown,
as a group, to be under higher oxidative stress and
have reduced levels of antioxidants as compared with
controls

EmilyV
Posts: 75
Joined: Thu Feb 09, 2017 9:41 pm

Re: Mitochondrial dysfunction in autism spectrum disorders

Postby EmilyV » Sun Apr 30, 2017 11:01 pm

Dr. Richard Frye is a great autism researcher, his articles are worth reading, there is a bunch on pubmed. One of the ideas he proposes that some bacteria in the gut produce propionic acid which is toxic to mitochondria and result in ASD Symptoms. His research is very convincing.
Here is another good article.
https://www.ncbi.nlm.nih.gov/pubmed/23340503

Marya
Posts: 220
Joined: Tue Feb 21, 2017 4:14 pm

Re: Mitochondrial dysfunction in autism spectrum disorders

Postby Marya » Thu May 11, 2017 11:25 pm

Thanks @AspieGenes for this review. I think it makes sense now that taking Acetyl l carnitne is benefical for autistics to maintain Mitochondria dysfunction. I already read about it in a brain book for a neurologist, it is almost good for any brain disorders.


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