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Mitochondrial dysfunction in autism spectrum disorders

Posted: Sat Oct 29, 2016 1:56 pm
by AspieGenes
New study, goes along with my theory on Sulfite Oxidase, a mitochondrial enzyme, being at the center of ASD.

Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis
http://sci-hub.cc/10.1038/mp.2010.136

Secondary mitochondrial dysfunction in ASD
A majority (79%) of the children with ASD/MD
identified in this review did not possess a genetic
etiology that might account for mitochondrial dysfunction.
Although a yet unidentified genetic defect
may be present in some of these cases, secondary
mitochondrial dysfunction is likely.9,85 Biochemical
abnormalities reported in some children with
ASD could contribute to secondary mitochondrial
dysfunction. For example, several studies have
documented a significantly lower mean GSH concentration110,130,185–189
and a lower mitochondrial GSH
reserve35 in children with ASD as compared with
controls. GSH depletion is associated with impaired
mitochondrial function73 and increased ROS production.36
Increased ROS can impair mitochondrial
function36,190 and may be particularly significant in
individuals with ASD because they have been shown,
as a group, to be under higher oxidative stress and
have reduced levels of antioxidants as compared with
controls

Re: Mitochondrial dysfunction in autism spectrum disorders

Posted: Sun Apr 30, 2017 11:01 pm
by EmilyV
Dr. Richard Frye is a great autism researcher, his articles are worth reading, there is a bunch on pubmed. One of the ideas he proposes that some bacteria in the gut produce propionic acid which is toxic to mitochondria and result in ASD Symptoms. His research is very convincing.
Here is another good article.
https://www.ncbi.nlm.nih.gov/pubmed/23340503

Re: Mitochondrial dysfunction in autism spectrum disorders

Posted: Thu May 11, 2017 11:25 pm
by Marya
Thanks @AspieGenes for this review. I think it makes sense now that taking Acetyl l carnitne is benefical for autistics to maintain Mitochondria dysfunction. I already read about it in a brain book for a neurologist, it is almost good for any brain disorders.