FatherOf2 wrote:I ended up purchasing the complete mutation report from nutrahacker. The neurotransmitter section is quite interesting and explains a lot of things I see in my son. In addition to the homozygous MOA-A mutation, he has:
DAOA rs701567 (+/+) - D-amino acid oxidase activator, which degrades D-serine, a potent activator of NMDA receptors. Associated with cognitive manic symptoms, Need Idebenone, Piracetam, Magnesium, Taurine, Lithium orotate. I see my old friends Piracetam and Taurine on this list.
GAD1 rs3749034 (+/+), GAD1 rs3828275 (+/+) - Catalyzes production of GABA from glutamate. High glutamate, low GABA. Need Taurine, Theanine, NAC, Glycine, Vitamin B3. Avoid MSG.
Basically, these mutations tell me that my son has high glutamate, which probably explains his hyperactivity, stimming, abnormal EEG. He also have high serotonin, dopamine, epinephrine, and norepinephrine which explain his anger issues. So, the stuff he needs:
- B2 R-5-P (promote MAO-A)
- Hydroxy B12 (degrade catecholamines)
- Ornithine (to reduce ammonia due to MTHFR mutation, already taking it)
- Taurine (help with GABA, already taking it, perhaps I will start giving it twice a day)
- NAC (need for his affected detox genes)
Progesterone can help with his MAO-A mutation. He also has two homozygous mutations leading to high estrogen. Nutrahacker recommends DIM (Diindolylmethane), which is an interesting hormone-balancing supplement. I am a bit scared messing with hormones at this time.
Fo2 just my two cents... I did the nutrahacker few months ago and the results scared the hell out of me... Started ordering supplements not much worked, saw little progress but nothing major etc
Then by coincidence I was speaking to one of the of the dads at school who is actually a professor/lecturer/researcher in top university here in London in biomed (of all things!!) and he said tests like 23andme etc only look at very small part of the genes, and to get the actual full picture you need to do the full DNA essay which costs thousands of dollars (that's one of the things he does) . He did say that genes/SNPs etc work as a team and compensate each other and so unless something is extremely obvious It's not great idea to rely on 23andme results etc as in most cases the results are not reliable...
Anyhow so many people out there have worst genes than us, why are we the autistic one? Hence I personally stopped going for the nutrahacker recommendations and just trying to remove the brain inflammation and the bacteria issues instead
By all means though go for it and i hope it works for u