In 1927, the Austrian psychiatrist, Julius Wagner-Jauregg won a Nobel Prize for treating psychosis with malaria... The impact of deliberately giving malaria to schizophrenics was ... unexpected... As the first fever took hold, a few days after the deliberate infection, the schizophrenic patients seemed to lose their psychosis. But sadly, when the fever came down, the psychosis returned... Horrobin argued that an inability to flush [from Niacin], the failure to feel pain, the beneficial effects of fever, and the resistance to arthritis seen in schizophrenics were all linked to arachidonic acid abnormalities. Arachidonic acid is usually locked up in membrane phospholipids, but for the body to react to many different stimuli it must be released as free arachidonic acid which can then regulate cell function in appropriate ways. Some arachidonic acid is also then converted to prostaglandins that open up blood vessels to allow faster blood flow. Horrobin argued that in schizophrenics, a shortage of free arachisonic acid could explain a lack of prostaglandins and, hence, of flushing... During a fever, arachidonic acid is very rapidly released from the cell membranes since it helps to defend against infection. If schizophrenics are usually deficient in arachidonic acid, fever may move body levels towards the norm improving brain function and reducing psychotic symptoms.
Next, this study "Efficacy of Adding Large Doses of Arachidonic Acid to DHA against Restricted Repetitive Behaviors in Individuals with Autism Spectrum Disorders" https://www.omicsonline.org/efficacy-of-adding-large-doses-of-arachidonic-acid-to-docosahexaenoic-acid-against-restricted-2155-6105.S4-006.php?aid=3211:
It has been documented that behavioral addictions resemble substance addiction in many domains, including the repetitive patterns of interests and behavior displayed by addicts and their failure to resist impulses to perform an act that are harmful to themselves or others. Restricted and repetitive patterns of interests and behavior resembling the characteristics of behavioral addictions are also a core feature of autism spectrum disorders (ASD)... The polyunsaturated fatty acids, arachidonicacid (ARA) and docosahexaenoic acid (DHA) play key roles in the maturation of the brain network. Supplementation of larger doses of ARA added to DHA may therefore improve repetitive and addictive behavior... Our supplementation regimen significantly ... reduced repetitive and addictive behaviors ...[and] the scores of the ABC-measured social withdrawal and ABC-measured inappropriate speech. These findings suggest that improvements in impaired social interactions may contribute to improvements in repetitive and addictive behavior.
Many parents here including me observed that their kids improved significantly during flu fevers. The above theory may explain it. My son also significantly improved on Evening Primerose Oil, which is 73% made of ARA. The improvements were temporary though. Some adults claim that ARA helps them with anxiety and social phobia while fish oil does nothing.